Chemistry, Formulations and Base Rates

Medicinal chemistry services include the custom synthesis of small molecule compounds for use in both in vitro and in vivo biological studies. Most compounds can be prepared on a scale of anywhere from 100 mg to 10 grams. Preparation of small libraries of compounds (20-25 analogs at 5-10 mg each) for screening and the development of structure-activity relationships is also available. Compound characterization and analysis includes 1H NMR, 13C NMR, HRMS, and if appropriate, optical rotation.

Note: Prior to any of the following services, the cost of the project will be agreed upon. The total cost will be based on the following services and rates, but will depend upon the nature and complexity of the project.

Medicinal and Synthetic Chemistry Baseline Fees

Synthesis of small molecule tool compounds with purity ≥ 95% by HPLC and 1H NMR and structure confirmed by 1H NMR, 13C NMR, and HRMS.

Synthesis of 1 to 10 grams (1 gram minimum)

Research plan development $340 flat fee
Chemicals, reagents, solvents, supplies, etc $799 per gram
Technician costs $54 per hour
Baseline estimate (18 h) $972
Faculty consulting and review $177 per hour
baseline estimate (2 h) $354

 

Baseline cost examples

Tool Compound Amount Total costs
1.0 gram $2,465
2.5 grams $3,664
5.0 grams $5,661
7.5 grams $7,658
10 grams $9,656

 

Synthesis of libraries of 10-20 new chemical entity analogs based on a hit and/or lead compound in amounts of 3-10 mg each with purity ≥ 95% by HPLC and 1H NMR and structure confirmed by 1H NMR and HRMS.

Synthesis of 20 NCE analogs

Research plan development $340 flat fee
Chemicals, reagents, solvents, supplies, etc. $1295
Technician costs $54 per hour
baseline estimate (42 h) $2,268
Faculty consulting and review $177 per hour
baseline estimate (4 h) $708

 

Baseline cost examples

20 NCE Analogs Summary $4,611
  • All studies are designed to meet the requirements of the Sponsor, the budget will vary based on multiple design factors such as but not limited to: number of analogs requested complexity of chemical synthesis, number of synthetic steps, cost of requisite building blocks and reagents, number of regions in the scaffold to be scanned, required solvents and volumes of solvents, number and type of purifications, and yield of synthetic transformations.

 

Formulation Fees

Service Priced by Cost
Solubility Compound $120
Dissolution testing – up to 24 hour release Formulation $1500
Dissolution testing – 1+ week release Formulation per week
Differential scanning calorimetry Compound/formulation $200
Thermogravimetric analysis Compound/formulation $200
X-ray powder diffraction Compound/formulation $200
Dynamic light scattering particle size and zeta potential Formulation $75
Mastersizer particle size analysis Formulation $75
  • These are the basic rates, but all studies are designed to meet the requirements of the Sponsor. The actual budget will vary based on multiple factors, including the complexity of the study design and analyses, nature of the compound and formulation, and any additional consultation time needed.

 

Fees for Basic Ocular Hypertension Study to Evaluate Neuroprotection*

Examples of Add-on Costs (per animal)

Anterograde axon transport analysis $150
Retinal ganglion cell Quantification $400
Optic nerve axon quantification $300
Greater than weekly IOP measurement $100
Greater than single drug dosing $50-$100
PERG/VEP in rat (includes establishing baseline and 1 testing session) $250
PERG/VEP in mouse (includes establishing baseline and 1 testing session) $250
Intraocular injection $100

 

*All studies are designed to meet the requirements of the Sponsor, actual study budget will vary based on multiple design factors such as but not limited to: strain of animal being used, animal source/vendor, dose regimen being used, formulation requirements, endpoint parameter(s), study timeline, samples (tissues) and processing, plating media, personnel required, dose route, diagnostic tests (if applicable), number of time points, sample shipment, outsourced tests, method development.

Fees for Testing the Efficacy of Ocular Drug Delivery System*

Services provided by the PI Cost per hour
Study design and protocol preparation $120
Animal (IACUC) protocol preparation $120
Data analysis and trouble shooting $200
Consultation $120
Experiments Cost per animals
Animal anesthesia $30
Administering topical medications $20
Fundus imaging $150
Fluorescent imaging $250
 Eye dissection $50
Immunohistochemical staining $150

 

  • These are the basic rates. All studies are designed to meet the requirements of the Sponsor. Thus, services will vary due to the complexity of the analyses, need for method development, sample processing and any additional consultation time needed.