Hongli Wu PhD

The central theme of my research is to understand the function of thiol-regulating enzymes and evaluate their therapeutic potential in eye diseases. Of primary interest is the age-related macular degeneration (AMD), the most common retinal disorder that affects 25 million people worldwide, yet its pathogenesis remains poorly understood. The following are our major projects:

  • Examine how retinal thiol redox dysregulation leads to AMD pathogenesis.
  • Characterize glutaredoxin 2 (Grx2), a thiol redox-regulating enzyme, knockout mice as a new animal model for AMD.
  • Identify/screening Grx2 inducers from natural products for AMD treatment

Recent publications