School of Public Health

Clinical Trial / Intervention Design and Efficacy Evaluation

Clinical Trial Intervention Des Efficacy Eval3Intervention development and evaluation involve dynamic and iterative processes which can include conceptualizing and designing interventions, feasibility, pilot or efficacy testing, as well as full-scale effectiveness and implementation trials.


  • Brayton RP, Price AM, Jones C, Ellis C, Burkhart S, Knell G. Prospective evaluation of 24-hour movement behaviors among adolescents recovering from a sport-related concussion.Applied Neuropsychology: Child, 1-9. doi; 10.1080/21622965.2023.2181082
  • Knell G, Burkhart SO, Gabriel KP. Need to clarify mechanisms explaining the effect of screen time on recovery from concussion. JAMA Pediatrics. Published online 2021 Dec 13; doi: doi:10.1001/jamapediatrics.2021.5339.
  • Knell G, Caze II TJ, Burkhart SO. Evaluation of the vestibular and ocular motor screening (VOMS) as a prognostic tool for protracted recovery following paediatric sports-related concussion. BMJ Open Sport Exerc Med. 2021;7(1):e000970. doi: 10.1136/bmjsem-2020-000970. eCollection 2021. PubMed PMID: 33868706; PubMed Central PMCID: PMC7996664..
  • Businelle, M. S., Walters, S. T., Mun, E-Y., Kirchner, T. R., Hebert, E. T., & Li, X. (2020). Reducing drinking among people experiencing homelessness: protocol for the development and testing of a just-in-time adaptive intervention. JMIR Research Protocols, 9(4), e15610.
  • Chung, T., Bae, S. W., Mun, E.-Y., Suffoletto, B., Jang, S., & Dey, A. (2020). Mobile assessment of acute effects of marijuana on cognitive functioning in young adults: A pilot study. JMIR mHealth and uHealth, 8(3), e16240
  • Larimer, M. E., Witkiewitz, K., Schwebel, F. J., Lee, C. M., Lewis, M. A., Kilmer, J. R., Andersson, C., Johnsson, K., Dillworth, T., Fossos-Wong, N., Pace, T., Grazioli, V. S., & Berglund, M. (2021). An International Comparison of a Web-Based Personalized Feedback Intervention for Alcohol Use During the Transition out of High School in the United States and Sweden. Prevention Science, 22, 670-682. DOI: 10.1007/s11121-021-01231-w
  • Lee, C. M., Cadigan, J., Kilmer, J, Cronce, J., Suffoletto, B., Walter, T., Fleming, C., & Lewis, M. A. (2021). Brief Alcohol Screening and Intervention for Community College Students (BASICCS): Feasibility and Preliminary Efficacy of Web-conferencing BASICCS and Supporting Automated Text Messages. Psychology of Addictive Behaviors, 35, 840-851. DOI: 10.1037/adb0000745
  • Lewis, M. A., Rhew, I. C., Fairlie, A. M., Swanson, A. Anderson, J. & Kaysen, D. L. (2019). Evaluating personalized feedback intervention framing with a randomized controlled trial to reduce young adult alcohol-related sexual risk taking. Prevention Science, 310-320.
  • Lewis, M. A., Patrick, M. E., Litt, D. M., Blayney, J. A., Atkins, D. C., Kim, T., Norris, J., George, W. H., & Larimer, M. E. (2014). Randomized controlled trial of a web-delivered personalized normative feedback intervention to reduce alcohol-related risky sexual behavior. Journal of Consulting and Clinical Psychology, 82, 429-440. 10.1037/a0035550 PMCID: PMC4029925
  • Lewis, M. A., Litt, D. M., Fairlie, A. M., Kilmer, J. R., Kannard, E., Resendiz, R., & Walker, T. (2022). Investigating Why and How Young Adults Utilize Protective Behavioral Strategies for Alcohol and Marijuana Use: Protocol for Developing a Randomized Controlled Trial. JMIR Research Protocols, 11, e37106.
  • Ray, A. E., Mun, E.-Y., Lewis, M. A., Litt, D. M., Stapleton, J. L., Tan, L., Buller, D., Zhou, Z., Bush, H., & Himelhoch, S. S. (2023). Cross-tailoring integrative alcohol and risky sex feedback for college students: A hybrid type 1 effectiveness-implementation trial. JMIR Research Protocols, 12, e43986.
  • Litt, D. M., Geusens, F., Seamster, A., & Lewis, M. A. (2022). A parent-based intervention for reducing high-risk social media cognitions, alcohol use, and negative consequences among adolescents: Protocol for a randomized controlled pilot study. JMIR Research Protocols, 11, e38543.
  • Mun, E.-Y., von Eye, A., & White, H. R. (2009). An SEM approach for the evaluation of intervention effects using pre-post-post designs. Structural Equation Modeling, 16(2), 315-337.
  • Walters, S. T., Ondersma, S. J., Ingersoll, K. S., Rodriguez, M., Lerch, J., Rossheim, M. E., & Taxman, F. S. (2014). MAPIT: Development of a web-based intervention targeting substance abuse treatment in the criminal justice system. Journal of Substance Abuse Treatment, 46, 60-65.
  • Walters, S. T., Mun, E.-Y., Tan, Z., Luningham, J. M., Hebert, E., Oliver, J. A., & Businelle, M. S. (2022). Feasibility and preliminary effectiveness of a smartphone-based just-in-time adaptive intervention for adults with alcohol misuse who are experiencing homelessness. Alcoholism: Clinical and Experimental Research.