Orson Moe, M.D.
Professor, Department of Internal Medicine & Physiology
UT Southwestern Medical Center
“Uremic Cardiovasculopathy”
Chronic kidney disease has reached epidemic proportions in the USA and worldwide. A majority of the morbidity and mortality is due to cardiovascular disease. In addition to the traditional Framingham risk factors, there are metabolic factors from the internal milieu in kidney disease that drive uremic cardiovasculopathy. Three factors (amongst many) that are related to mineral metabolism and are severely deranged in chronic kidney disease are phosphate toxicity, excess fibroblast growth factor-23, and Klotho deficiency. These three disturbances interact to synergistically incite and worsen cardiovascular function. Data from human studies, and animal and cell models, all contribute to the development of diagnostic, prognostic, and eventually therapeutic venues to treat this deadly disease. Until one has a way to prevent or reverse kidney damage, or devise non-allogenic organ transplant, the best and perhaps only way to save kidney patients is to ameliorate the cardiovascular complications.
Friday, February 8, 2019, 11:00AM-12:00PM, LIB-110
University of North Texas Health Science Center
Fort Worth, Texas