NIH R01: Understanding the Intersection of Social Inequities to Optimize Health and Reduce Health Disparities: The Axes Initiative

Funding Opportunity: RFA-NR-24-006

Deadlines: July 5, 2024, February 14, 2024


Research shows that intersecting systems of privilege and oppression produce and sustain wide and unjust variations in health. The Axes Initiative will support research to understand health at the intersections of social statuses such as race, ethnicity, socioeconomic status, sexual orientation, and ability, by examining contributions of social and other determinants of health.

This funding opportunity solicits research to examine the pathways through which social determinants of health (SDOH), and related biological, psychological, and behavioral factors impact health and health disparities at intersections of privileged and/or oppressed social statuses such as race, ethnicity, socioeconomic status, sexual orientation, and ability. SDOH is a required pathway of focus. Observational research, evaluation studies, simulation studies, and predictive modeling studies are of interest. Also of interest are mixed-methods studies that combine quantitative and qualitative data to contextualize intersectional forms of privilege and oppression. Projects using longitudinal study designs are encouraged.

The primary populations of focus for the Axes Initiative are those that experience health disparities in the U.S., including racial and ethnic minority populations, people with lower socioeconomic status, underserved rural populations, sexual and gender minority populations, and people with disabilities. Inclusion of social statuses such as gender and gender identity, sex assigned at birth, national origin, and immigration status are also of interest. Studies must clearly convey the populations of interest for the proposed research and how the populations comprise intersecting statuses that are privileged or have been oppressed.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

For more information, please see the opportunity webpage.