Notice Number: NOT-DE-23-005
Deadline: October 5, 2023
Purpose
The National Institute of Dental and Craniofacial Research (NIDCR) is issuing this Notice of Special Interest (NOSI) to encourage research on prenatal environmental and physical stressors experienced by women during pregnancy that affect their child’s dental, oral, and craniofacial (DOC) tissues through altered maternal physiology. The purpose of this NOSI is to support research elucidating the impact of maternal, environmental, nutritional, pharmaceutical, and/or infectious exposures upon the developing and formed oral and craniofacial complex.
This NOSI encourages studies addressing the relationship between maternal health and the developing craniofacial complex of their children. Research areas of interest includes, but is not limited to, the following:
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- Studies elucidating the interplay of prenatal maternal health including biologic, immunologic, infectious, and/or downstream signaling pathways that disrupt DOC tissues in human offspring and in animal models.
- Existing cohort studies using exfoliated deciduous teeth as biomarkers that measure intensity and timing of maternal environmental exposures to correlate with DOC phenotypes in their children.
- Observational and mechanistic studies of pregnant mothers who have undergone emotional stress during pregnancy and its impact on the developing teeth and craniofacial structures of their children.
- Epidemiologic studies comparing maternal prenatal health and disease and their children’s dental and craniofacial development to gain a better understanding of underlying disease mechanisms.
- Observational and mechanistic studies monitoring the maternal prenatal exposome (e.g., dietary habits, tobacco, opioids, trauma) and the DOC development of their children.
For more information, please see the opportunity website.