PAR-23-212: Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD & other ADRDs (R01 – Clinical Trial Not Allowed)
Purpose: This Notice of Funding Opportunity (NOFO) supports studies establishing deeper mechanistic insights and causal cellular and molecular relationships between TDP-43 pathology and clinical phenotypic outcomes. Additionally, it requires comparisons between at least two TDP-43 proteinopathies, one of which must be an Alzheimer’s Disease-Related Dementia (ADRD), such as, but not limited to, Limbic-predominant Age-related TDP-43 Encephalopathy (LATE), with or without Alzheimer’s disease neuropathological change (AD-NC), or Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), to further understand distinct and overlapping mechanisms in these syndromes.
Deadline: October 4, 2023
For more detailed information, please see the opportunity announcement.