Publications

Research Papers

Cushen SC, Sprouse ML, Blessing A, Sun J, Jarvis SS, Okada Y, Fu Q, Romero SA, Phillips NR, Goulopoulou S. (2020) Cell-free mitochondrial DNA increases in maternal circulation during healthy pregnancy: a prospective, longitudinal study. Am J Physiol Regul Integr Comp Physiol. Feb 1;318(2):R445-R452. PMID: 31913687.

Osikoya O, Ahmed H, Panahi S, Bourque SL, Goulopoulou S. (2019) Uterine Perivascular Adipose Tissue Is A Novel Mediator of Uterine Artery Blood Flow. J Physiol. Aug;597(15):3833-3852. PMID: 31165480

Ahmed H, Hannan JL, Apolzan JW, Osikoya O, Cushen SC, Romero SA, Goulopoulou S. A free-choice high-fat high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R472-R485. PMID: 30758976.

Osikoya O, Jaini PA, Nguyen A, Valdes M, Goulopoulou S. Effects of low-dose aspirin on maternal blood pressure and vascular function in an experimental model of gestational hypertension.  Pharmacological Research 2017 Jun; 120:267-278. PMID: 28412461.

Goulopoulou S, Wenceslau CF, McCarthy CG, Matsumoto T, Webb RC. Exposure to Stimulatory CpG Oligonucleotides During Gestation induces Maternal Hypertension and Excess Vasoconstriction in Pregnant Rats. Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H1015-25.  PMID: 26873968.

Reviews, Chapters, Commentary

Loria AS, Goulopoulou S, Bourque SL, Davidge ST. (2019) Sex Differences in Developmental Origins of Cardiovascular Dysfunction. In: Sex Differences in Cardiovascular Physiology and Pathophysiology. Eds.: LaMarca B, Alexander BT. Elsevier Science. ISBN 0128131977, 9780128131978

Brennan LJ, Goulopoulou S, Bourque SL. (2019) Prenatal therapeutics and programming of cardiovascular function. Pharmacol Res Jan;139:261-272. PMID: 30458216

Chaudhari S, Cushen SC, Osikoya O, Jaini P, Posey R, Mathis KW, Goulopoulou S. (2018) Mechanisms of sex disparities in cardiovascular function and remodeling. Compr Physiol. Dec 13;9(1):375-411.

Bourque SL, Goulopoulou S. (2018) Special issue: “Perinatal therapeutics: Novel approaches to target adverse pregnancy outcomes and shape offspring health“. Pharmacol Res Nov;137:250-251. PMID: 30321598.

Goulopoulou S. (2018) Calpain: A Novel Mediator of MPO (Myeloperoxidase)-Induced Endothelial Dysfunction. Hypertension. Apr;71(4):574-576. PMID: 29507102

Goulopoulou S. (2017) Vascular endothelium: a potential source of podocalyxin in serum from pregnancies with preeclampsia. Journal of Hypertension. Nov;35(11):2176-2177. PMID: 28953590

Goulopoulou S. Maternal Vascular Physiology in Preeclampsia. (2017) Hypertension. Hypertension. Dec;70(6):1066-1073. PMID: 30549017.

Cushen SC, Goulopoulou S. (2017) New Models of Pregnancy-Associated Hypertension. Am J Hypertens. Nov 1;30(11):1053-1062. PMID: 28472224.

Goulopoulou S. (2016) Switching Gears After Graduate School: From Applied Human Physiology to Basic Science. Physiologist. Mar;59(2):91-4. PMID: 27120863.

Goulopoulou S, McCarthy CG, Webb RC. (2016) Toll-like Receptors in the Vascular System: Sensing the Dangers Within. Pharmacol Rev. Jan;68(1):142-67. PMID: 26721702; PMCID: PMC4709508.

Goulopoulou S, Davidge ST. (2015) Molecular mechanisms of maternal vascular dysfunction in preeclampsia. Trends Mol Med. Feb;21(2):88-97. PMID: 25541377.

Matsumoto T, Goulopoulou S, Taguchi K, Tostes RC, Kobayashi T. (2015) Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol. Aug;172(16):3980-4001. PMID: 26031319; PMCID: PMC4543607.

Abstracts

1. Cushen SC, Silzer T, Reid D, Sun J, Scroggins SM, Santillan MK, Santillan DA, Phillips NR, Goulopoulou S. Absolute Quantification of Mitochondrial DNA in Peripheral Blood from Women with Preeclampsia. Society for Reproductive Investigation, March 10-14, 2020, Vancouver, CA. *This abstract was accepted for poster presentation, but the conference was cancelled due to COVID19 travel ban
2. Singhal J, Osikoya O, Cushen SC, Wilson EN, Mabry S, Cunningham RL, Goulopoulou S. Postpartum Maternal Vascular Function in a Rat Model of Gestational Obstructive Sleep Apnea. Experimental Biology, April 4-7, 2020, San Diego, CA. *This abstract was accepted for poster presentation, but the conference was cancelled due to COVID19 travel ban
3. Cushen SC, Osikoya O, Blessing A, Phillips NR, Goulopoulou S. Placental Exposure to Hypoxia and Oxidative Stress Causes Mitochondrial DNA Release into the Extracellular Space. Experimental Biology, April 6-9, 2019, Orlando, FL.
4. Osikoya O, Ahmed H, Panahi S, Bourque SL, Goulopoulou S. Uterine perivascular adipose tissue: A novel regulator of uterine artery hemodynamics during normal pregnancy. Experimental Biology, April 6-9, 2019, Orlando, FL.
5. Riaz M, Cushen SC, Phillips NR, Goulopoulou S. Inhibition of Mitochondrial Respiratory Chain Complex I Induces Vascular Endothelial Cell Apoptosisand Release of Mitochondrial DNA. Experimental Biology, April 6-9, 2019, Orlando, FL.
6. Nguyen RT, Cushen SC, Phillips NR, Goulopoulou S. Mitochondrial oxidative stress and extrusion of mitochondrial DNA from endothelial cells: implications for maternal endothelial dysfunction in preeclampsia. Research Appreciation Day, University of North Texas Health Science Center, March 29, 2019.
7. Osikoya O, Goulopoulou S. Pregnancy Mediates the Inflammatory and Vasoactive Effects of Uterine Perivascular Adipose Tissue. Society for Reproductive Investigation, March 6-10, 2018, San Diego, CA.
8. Ahmed H, Goulopoulou S. Free access to lard, sucrose, and chow results in expansion of rat periuterine adipose tissue. Research Appreciation Day, University of North Texas Health Science Center, April 6, 2018.
9. Osikoya O, Goulopoulou S. Pregnancy Augments the Vasoactive, Metabolic, and Inflammatory Functions of Uterine Perivascular Adipose Tissue. Research Appreciation Day, University of North Texas Health Science Center, April 6, 2018. Oral Presentation.
10. Cushen S, Blessing A, Chaudhari S, Patil S, Phillips NR, Goulopoulou S. Trophoblast cells exposed to hypoxia and oxidative stress release mitochondrial DNA and undergo apoptosis. Research Appreciation Day, University of North Texas Health Science Center, April 6, 2018.
11. Osikoya O, Goulopoulou S. Pregnancy Promotes Inflammation and Pro-contractile Effects in Uterine Perivascular Adipose Tissue. Society for Reproductive Investigation, March 6-10, 2018, San Diego, California.
12. Osikoya O, Goulopoulou S. Pregnancy Promotes Inflammation and Pro-contractile Effects in Uterine Perivascular Adipose Tissue. Experimental Biology conference, San Diego, CA, April 21-26, 2018.
13. Nguyen R, Chaudhari S, Osikoya O, Goulopoulou S. Nuclear expression of nuclear factor erythroid 2-related factor 2 in trophoblast cells in response to hypoxia. Research Appreciation Day, University of North Texas Health Science Center, April 7, 2017.
14. Chaudhari S, Phillips NR, Sprouse M, Jarvis SS, Okada Y, Morton J, Davidge ST, Fu Q, Goulopoulou S. Circulating Cell-free Mitochondrial DNA In Normal Human Pregnancy and In Experimental Preeclampsia, Research Appreciation Day, University of North Texas Health Science Center, April 7, 2017.
15. Cushen S, Osikoya O, Goulopoulou S. L-Sulforaphane Decreased Contractile Response in Mesenteric Arteries in a Rat Model of Gestational Hypertension, Research Appreciation Day, University of North Texas Health Science Center, April 7, 2017.
16. Dimos BA, Osikoya O, Jaini PA, Nguyen A, Valdes M, Goulopoulou S. Exposure to Synthetic CpG DNA during pregnancy Increases Expression and Activity of Cyclooxygenase in Maternal Arteries. Research Appreciation Day, University of North Texas Health Science Center, April 7, 2017.
17. Goulopoulou S, Sprouse M, Phillips NP, Jarvis SS, Okada Y, Fu Q. Circulating Cell-free DNA and Maternal Cardiovascular Responses In Healthy Pregnancy And Postpartum, Experimental Biology conference, Chicago, IL, April 22-26, 2017. Oral Presentation.
18. Cushen S, Osikoya O, Goulopoulou S. L-Sulforaphane Decreased Contractile Response in Mesenteric Arteries in a Rat Model of Gestational Hypertension, Experimental Biology conference, Chicago, IL, April 22-26, 2017.
19. Osikoya O, Goulopoulou S. Uterine Perivascular Adipose Tissue Potentiates Contractile Responses in Uterine Arteries from Pregnant rats.  International Symposium of Mechanisms of Vasodilation, Mayo Clinic, Rochester, MN, USA – November 6-9, 2016
20. Posey R, Hannan JL, Webb RC, Goulopoulou S. Multiparity has beneficial effects on vascular function in an experimental model of type 2 diabetes.  Research Appreciation Day, University of North Texas Health Science Center, April 15, 2016.
21. Osikoya O, Goulopoulou S. Uterine Perivascular Adipose Tissue Potentiates Contractile Responses in Uterine Arteries from Pregnant rats.  Society for Reproductive Investigation, March 15-19, 2016, Montreal, Canada.
22. Jaini PA, Nguyen A, Valdes V, Osikoya O, Goulopoulou S.  Low-dose Aspirin During Gestation Promotes Vascular Dysfunction and does not Ameliorate Maternal Hypertension in Rats Exposed to Innate Immune System Activation.  Experimental Biology conference, April 2-6, 2016.