Jonathan Tune

Johnathan Tune, Ph.D.Tune

Professor and Chair


  • Ph.D., University of North Texas Health Science Center (1997)
  • B.A., University of North Texas PhD (1994)

Curriculum Vitae
Google Scholar
Research Gate

Personal Bio
Johnathan Tune received his Ph.D. in the laboratory of Dr. H. Fred Downey at the University of North Texas Health Science Center in Fort Worth, Texas. He performed his post-doctoral work in the laboratory of Dr. Eric Feigl at the University of Washington School of Medicine in Seattle, Washington. Dr. Tune has held academic positions at the University of North Texas Health Science Center, Louisiana State University Health Sciences Center (New Orleans, LA), and the Indiana University School of Medicine. Dr. Tune serves on study sections for the American Heart Association and the Heart, Lung and Blood Institute of the National Institutes of Health and served on the editorial board of leading cardiovascular journals, including the American Journal of Physiology Heart and Circulatory Physiology, Basic Research in Cardiology, and Circulation Research. His research has been funded by the American Diabetes Association, the American Heart Association, Eli Lilly and Company, and the National Institutes of Health.

Research Interests
Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.

Research Keywords

Coronary circulation, cardiac function, obesity, vascular function

Current Funding

NIH HL136386 – Mineralocorticoid receptor dependent coronary vascular dysfunction in obesity  Eli Lilly and Company – SGLT2 inhibitors and sodium hydrogen exchanger-1: a potential link to cardioprotective benefits

Selected Publications

Click here for a complete list of publications (

Teaching Interests

  • Cardiovascular Physiology
  • Respiratory Physiology

Teaching Statement

Throughout my career I have remained actively involved with teaching both graduate and medical students. My teaching philosophy is primarily “Socratic” in nature as I work to actively promote student interaction through probing questions to stimulate interactive discussion of the key concepts being covered. I have also been involved in promoting/evaluating formation of novel courses and approaches to teaching.  Tune JD, Sturek M, Basile DP. Flipped classroom model improves graduate student performance in cardiovascular, respiratory and renal physiology. Adv Physiol Educ. 37:316-320, 2013.  Hopper M, Tune JD, Klabunde R. Small group activity to reinforce the impact of valvular defects and heart failure on cardiac pressure-volume relationships. MedEdPORTAL 14:10675, 2018.

National/International Committees and Service

  • Editorial Board—American Journal of Physiology Heart and Circulatory Physiology
  • Editorial Board—Basic Research in Cardiology
  • Editorial Board—Circulation Research, Experimental Biology and Medicine
  • Editorial Board—Microcirculation
  • Consulting Editor—American Journal of Physiology Heart and Circulatory Physiology
  • Councilor-Society for Experimental Biology and Medicine
  • Publications Committee-Microcirculatory Society
  • Nominating and Steering Committee-Cardiovascular Section of American Physiological Society
  • Animal Care Committee and Joint Programming Committee-American Physiological Society