Project 2 Publications

Simpkins JW, Perez E, Wang X, Yang S, Wen Y, Singh M. The potential for estrogens in  preventing Alzheimer’s disease and vascular dementia. Ther Adv Neurol Disord. 2009 Jan;2(1):31-49. doi: 10.1177/1756285608100427. PubMed PMID: 19890493; PubMed Central PMCID: PMC2771945.

Logan SM, Sarkar SN, Zhang Z, Simpkins JW. Estrogen-induced signaling attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity. Brain Res. 2011 Apr 6;1383:1-12. doi: 10.1016/j.brainres.2011.01.038. PubMed PMID: 21262203; PubMed Central PMCID: PMC3065978.

Yi KD, Perez E, Yang S, Liu R, Covey DF, Simpkins JW. The assessment of    non-feminizing estrogens for  use in  neuroprotection. Brain Res. 2011 Mar 16;1379:61-70. doi:10.1016/j.brainres.2010.11.058. Review. PubMed PMID:21111714; PubMed Central PMCID: PMC3048764.

Gatson JW, Liu MM, Abdelfattah K, Wigginton JG, Smith S, Wolf S, Simpkins JW, Minei JP. Estrone is neuroprotective in  rats  after traumatic brain injury. J Neurotrauma. 2012 Aug 10;29(12):2209-19. doi: 10.1089/neu.2011.2274. PubMed PMID: 22435710; PubMed Central PMCID: PMC3960846.

Richardson TE, Kelly HN, Yu AE, Simpkins JW. Therapeutic strategies in  Friedreich’s ataxia. Brain Res. 2013 Jun 13;1514:91-7. doi: 10.1016/j.brainres.2013.04.005. Review. PubMed PMID:23587934; PubMed Central PMCID: PMC4461031.

Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD, Brinton RD. Window of  opportunity for  estrogen and progestin intervention in  brain aging and Alzheimer’s disease. Brain Res. 2013 Jun 13;1514:1-2. doi:10.1016/j.brainres.2013.04.044. PubMed PMID: 23726132; PubMed Central PMCID: PMC4076427.

Barr TL, Simpkins J. Ischemic stroke: a  consequence of  a  diseased immune  system? Aging Dis. 2014 Oct 1;5(5):292-3. doi:10.14336/AD.2014.0500292. PubMed PMID: 25276488; PubMed Central PMCID: PMC4173795.

Brinkman SD, Reese RJ, Norsworthy LA, Dellaria DK, Kinkade JW, Benge J, Brown K, Ratka A, Simpkins JW. Validation of  a  self- administered computerized system to  detect cognitive impairment in older adults. J Appl Gerontol. 2014 Dec;33(8):942-62. doi:10.1177/0733464812455099. PubMed PMID: 25332303; PubMed Central PMCID: PMC4446715.

Chen F, Qi W, Sun J, Simpkins JW, Yuan D. Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in  the HT22 cell assay. Fitoterapia. 2014 Sep;97:156-63. doi:10.1016/j.fitote.2014.05.022. PubMed PMID: 24910000; PubMed Central PMCID: PMC4446712.

Doll DN, Barr TL, Simpkins JW. Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets. Aging Dis. 2014 Oct 1;5(5):294-306. doi: 10.14336/AD.2014.0500294. Review. PubMed PMID: 25276489; PubMed Central PMCID: PMC4173796.

Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA. Acarbose, 17-α- estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in  males. Aging Cell. 2014 Apr;13(2):273-82. doi:10.1111/acel.12170. PubMed PMID: 24245565; PubMed Central PMCID: PMC3954939.

Petrone AB, Gatson JW, Simpkins JW, Reed MN. Non-feminizing estrogens: a  novel neuroprotective therapy. Mol Cell Endocrinol. 2014 May 25;389(1-2):40-7. doi: 10.1016/j.mce.2013.12.017. Review. PubMed PMID: 24424441; PubMed Central PMCID: PMC4040321.

Petrone AB, Simpkins JW, Barr TL. 17β-estradiol and inflammation: implications for  ischemic stroke. Aging Dis. 2014 Oct 1;5(5):340-5. doi: 10.14336/AD.2014.0500340. Review. PubMed PMID:25276492; PubMed Central PMCID: PMC4173799.

Phillips NR, Simpkins JW, Roby RK. Mitochondrial DNA  deletions in Alzheimer’s brains: a  review. Alzheimers Dement. 2014 May;10(3):393-400. doi: 10.1016/j.jalz.2013.04.508. Review. PubMed PMID: 23850329; PubMed Central PMCID: PMC3800237.

Xie L, Sun F, Wang J, Mao X, Xie L, Yang SH, Su DM, Simpkins JW, Greenberg DA, Jin K. mTOR  signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after  focal  ischemia. J Immunol. 2014 Jun 15;192(12):6009-19. doi: 10.4049/jimmunol.1303492. PubMed PMID: 24829408; PubMed Central PMCID: PMC4128178.

Doll DN, Engler-Chiurazzi EB, Lewis SE, Hu H, Kerr AE, Ren X, Simpkins JW. Lipopolysaccharide exacerbates infarct size and results in  worsened post-stroke behavioral outcomes. Behav Brain Funct. 2015 Oct 13;11(1):32. doi: 10.1186/s12993-015-0077-5. PubMed PMID: 26463864; PubMed Central PMCID: PMC4604642.

Doll DN, Hu H, Sun J, Lewis SE, Simpkins JW, Ren X. Mitochondrial crisis in  cerebrovascular endothelial cells opens the blood-brain barrier. Stroke. 2015 Jun;46(6):1681-9. doi:10.1161/STROKEAHA.115.009099. PubMed PMID: 25922503; PubMed Central PMCID: PMC4418219.

Doll DN, Rellick SL, Barr TL, Ren X, Simpkins JW. Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity. J Neurochem. 2015 Feb;132(4):443-51. doi:10.1111/jnc.13008. PubMed PMID: 25492727; PubMed Central PMCID: PMC4459129.

Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW. Role of  Microvascular Disruption in Brain Damage from Traumatic Brain Injury. Compr Physiol. 2015 Jul 1;5(3):1147-60. doi: 10.1002/cphy.c140057. Review. PubMed PMID:26140712; PubMed Central PMCID: PMC4573402.

Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, Chen YW, Tan Z, Huber JD, Rosen CL. Common mechanisms of  Alzheimer’s disease and ischemic stroke: the  role of protein kinase C in the  progression of  age-related neurodegeneration. J Alzheimers Dis. 2015;43(3):711-24. doi:10.3233/JAD-141422. Review. PubMed PMID: 25114088; PubMed Central PMCID: PMC4446718.

Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K. The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders. Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi:10.1126/scitranslmed.aab1290. PubMed PMID: 26203081; PubMed Central PMCID: PMC4591937.

Qi W, Chen F, Sun J, Simpkins JW, Yuan D. Isolation and identification of  twelve  metabolites of    isocorynoxeine in  rat  urine and their neuroprotective activities in HT22 cell assay. Planta Med. 2015 Jan;81(1):46-55. doi: 10.1055/s-0034-1383357. PubMed PMID:25519834; PubMed Central PMCID: PMC4461055.

Ren X, Simpkins JW. Deciphering the Blood-Brain Barrier Damage in Stroke: Mitochondrial Mechanism. J Neuroinfect Dis. 2015 Oct;6(Suppl 2). pii: e002. PubMed PMID: 27213159; PubMed Central PMCID: PMC4873162.

Sarkar S, Jun S, Simpkins JW. Estrogen amelioration of    Aβ- induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ,  AKAP and Drp1. Brain Res. 2015 Aug 7;1616:101-11. doi: 10.1016/j.brainres.2015.04.059. PubMed PMID: 25964165; PubMed Central PMCID: PMC4464937.

Sun J, Ren X, Simpkins JW. Sequential Upregulation of  Superoxide Dismutase 2  and Heme  Oxygenase 1  by  tert-Butylhydroquinone Protects Mitochondria during Oxidative Stress. Mol Pharmacol. 2015 Sep;88(3):437-49. doi: 10.1124/mol.115.098269. PubMed PMID: 26082377; PubMed Central PMCID: PMC4551047.

Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD. Bryostatin extends tPA  time  window to 6 h  following middle cerebral artery occlusion in  aged female rats. Eur J Pharmacol. 2015 Oct 5;764:404-12. doi: 10.1016/j.ejphar.2015.07.035. PubMed PMID:26189021; PubMed Central PMCID: PMC4698807.

Bukeirat M, Sarkar SN, Hu H, Quintana DD, Simpkins JW, Ren X. MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c. J Cereb Blood Flow Metab. 2016 Feb;36(2):387-92. doi:10.1177/0271678X15606147. PubMed PMID: 26661155; PubMed Central PMCID: PMC4759667.

Engler-Chiurazzi EB, Singh M, Simpkins JW. From the 90’s to now: A brief historical perspective on more  than two decades of  estrogen neuroprotection. Brain Res. 2016 Feb 15;1633:96-100. doi:10.1016/j.brainres.2015.12.044. PubMed PMID: 26740397; PubMed Central PMCID: PMC4762740.

Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW. Impacts of  prenatal nanomaterial exposure on  male  adult Sprague-Dawley rat behavior and cognition. J Toxicol Environ Health A. 2016;79(11):447-52. doi: 10.1080/15287394.2016.1164101. PubMed PMID: 27092594; PubMed Central PMCID: PMC4899177.

Hu H, Doll DN, Sun J, Lewis SE, Wimsatt JH, Kessler MJ, Simpkins JW, Ren X. Mitochondrial Impairment in  Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity. Aging Dis. 2016 Jan 2;7(1):14-27. doi: 10.14336/AD.2015.0906. PubMed PMID: 26816660; PubMed Central PMCID: PMC4723230.

Petrone AB, O’Connell GC, Regier MD, Chantler PD, Simpkins JW, Barr TL. The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Transl Stroke Res. 2016 Apr;7(2):103-10. doi: 10.1007/s12975-015-0431-9. PubMed PMID:26515089; PubMed Central PMCID: PMC4770061.

Sarkar S, Jun S, Rellick S, Quintana DD, Cavendish JZ, Simpkins JW. Expression of  microRNA-34a in  Alzheimer’s disease brain targets genes linked to  synaptic plasticity, energy metabolism, and resting state network activity. Brain Res. 2016 Sep 1;1646:139-51. doi: 10.1016/j.brainres.2016.05.026. PubMed PMID: 27235866; PubMed Central PMCID: PMC4975975.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Longer lifespan in male mice  treated with a  weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or   a  Nrf2-inducer. Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. PubMed PMID: 27312235; PubMed Central PMCID:PMC5013015.

Sun J, Hu H, Ren X, Simpkins JW. Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol. 2016 Mar-Apr;54:15-21. doi: 10.1016/ PubMed PMID: 26827673; PubMed Central PMCID: PMC4789102.

Sun J, Ren X, Qi W, Yuan D, Simpkins JW. Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the ‘Neuronal Warburg Effect’. J Ethnopharmacol. 2016 Jul 1;187:249-58. doi: 10.1016/j.jep.2016.04.034. PubMed PMID:27114061; PubMed Central PMCID: PMC4887292.

Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW. Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol. 2017 Oct;157:188-211. doi: 10.1016/j.pneurobio.2015.12.008. Epub 2016 Feb 15. Review. PubMed PMID: 26891883; PubMed Central PMCID:PMC4985492.