November 5, 2015
The Use of Combination Antibiotic Therapy
- History of antibiotic combinations
- Rationale for combination therapy
- Advantages / disadvantage of combining antibiotics
- Testing regimens for combination therapy
William Weiss, Director, Pre-Clinical Services,
UNT Health Science Center
September 1, 2015
The University of North Texas Health Science Center Pre-Clinical Services group has recently become a part of the UNT System College of Pharmacy.
Myron Jacobson, PhD., Dean of the College of Pharmacy, said “I am delighted to announce that Jerry Simecka and William Weiss will be joining the faculty of the College of Pharmacy effective September 1, 2015. Additionally, the outstanding staff of the Pre-Clinical Services Program that they lead will also be joining the College. The staff members of the team include Mark Pulse, Assistant Director, David Valtierra, Kelly Peterson, Kiahrae, Carter, Phung Nyugen, Jessica Silva and Monica Castillo. Both Jerry and Bill have already been making high quality teaching contributions to our doctor of pharmacy program and we look forward to their continued involvement. Additionally, the outstanding Pre-Clinical Sciences Program integrates perfectly with the translational research efforts of the College of Pharmacy.”
The PreClinical Services group will continue to function as before, providing guidance and support for the research and development of new and novel therapies with an emphasis on infectious disease.
July 17, 2015
Dav132, an Adsorbent-Based Product, Protects the Gut Microbiome and Prevents Clostridium difficile Infections during Moxifloxacin Treatments
Jean De Gunzburg, PhD1, Amine Ghozlane, PhD2, Annie Ducher, MD1, Xavier Duval, MD, PhD3, Etienne Ruppé, PharmD, PhD2, Mark Pulse, MS4, Caroline Chilton, PhD5, Laurence Armand-Lefevre, PharmD, PhD6, Elisabeth Chachaty, PharmD, PhD7, Sakina Sayah-Jeanne, PhD1, Joël Doré, PhD2, Emmanuelle Le Chatelier, PhD2, Florence Levenez, BS2, Sean Kennedy, PhD2, Nicolas Pons, PhD2, William Weiss, MS4, Mark Wilcox, MD5,8, France Mentré, MD, PhD6, Antoine Andremont, MD, PhD6 and Stanislav Dusko Ehrlich, PhD2
(1)Da Volterra, Paris, France, (2)Metagenopolis, INRA, Jouy-en-Josas, France, (3)Bichat Claude Bernard Hospital; Paris 7 University, Paris, France, (4)UNT Health Science Center, Fort Worth, TX, (5)University of Leeds, Leeds, United Kingdom, (6)University Paris-Diderot Medical School and INSERM, UMR 1137, IAME, Paris, France, (7)Institut Gustave-Roussy, Villejuif Cedex, France, (8)Leeds Teaching Hospitals, Leeds, United Kingdom
June 24, 2015
The UNTHSC Pre-Clinical Services group will be in attendance at the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in San Diego, CA (September 17 – 21, 2015) and welcomes the opportunity to meet with current as well as prospective collaborators to discuss ongoing and future projects. If interested, please contact William Weiss (817-735-2111 or email@example.com) to arrange for a convenient dayand time to meet.
Efficacy of Carbavance (Meropenem-RPX7009) against Carbapenem-resistant E. coli in a murine UTI infection model
W. J. Weiss1, M. Pulse1, P. Nguyen1, K. Peterson1, J. Silva1, J. W. Simecka1, D. Valtierra1, M. Sabet2, D. C. Griffith2
1UNT Health Science Center, Ft. Worth, TX, 2 The Medicines Company, San Diego, CA
Efficacy of a Bacteriophage Cocktail in a Staphylococcus aureus Mouse Pneumonia Model is Comparable to Vancomycin
J. Shaw1,3*, W. J. Weiss2, M. E. Pulse2, S. M. Lehman1, F. Smrekar1, S. P. Morales1
1AmpliPhi Biosciences Corporation, Richmond, VA; 2 UNT Health Science Center, Fort Worth, TX; 3Hearts Consulting Group, Poway, CA.
January 30, 2015
President’s 2016 budget proposes historic investment to combat antibiotic-resistant bacteria to protect public health.
“We now have a national strategy to combat antibiotic-resistant bacteria, to better protect our children and grandchildren from the reemergence of diseases and infections that the world conquered decade ago”
– President Barack Obama’s remarks at the Global Health Security Agenda Summit, regarding the Executive Order to Combat Antibiotic Resistance, September 26, 2014.
January 27, 2015
The 25th European Congress of Clinical Microbiology and Infectious Disease (ECCMID) meeting will be held from April 25-28, 2015 in Copenhagen, Denmark. The meeting will feature a series of keynote lectures, symposia, educational workshops and meet-the-experts sessions on parallel tracks, covering the entire field of infectious diseases and clinical microbiology. Among the presentations will be:
Evaluating the induction potential of three antibiotics in the hamster Clostridium difficile infection model.
M. Pulse, T. Murphy, P. Nguyen, K. Peterson, J. Silva, J. Simecka, D. Valtierra, W. Weiss, S. Sayah-Jeanne, J. de Gunzburg
UNT Health Science Center, Fort Worth, TX & Dalvolterra, Paris, France
Efficacy evaluation of TP-271, a novel fluorocycline, in a neutropenic murine pneumonia model against susceptible and resistant gram-positive pathogens
W. Weiss, T. Murphy, M. Pulse, P. Nguyen, D. Valtierra, K. Peterson, J. Silva, J. Simecka, J. Sutcliffe, T. Grossman
UNT Health Science Center, Fort Worth, TX & Tetraphase Pharmaceuticals, Watertown, MA
Synthetic novel host defense protein mime tics for the treatment of gram-negative bacterial infections
S. Ram, K. Menon, R. Scott, D. Weaver, K. Freeman, G. Tew, W. Weiss, W. DeGrado, K. Fadela, A. Kumar, D. Brennan, S. Holden
Fox Chase Chemical Diversity Center, Doylestown, PA & UNT Health Science Center, Fort Worth, TX
January 15, 2015
UNTHSC PreClinical Services to present at the SMI 17th Annual conference on SuperBugs & SuperDrugs, March 25-26, 2015 in London, UK.
The Changing Role of Academia in Drug Discovery
- Historical perspective of academic involvement in drug development
- Growth of the modern pharmaceutical industry and detachment from academia
- Downturn in antibacterial discovery and development and current needs
- Collaboration of industry and academia in drug discovery
- Novel partnering models to increase innovation
William Weiss, Director of PreClinical Services, UNT Health Science Center
July 3, 2014
The UNTHSC Pre-Clinical Services group will be in attendance at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in Washington DC (September 5 – 9, 2014) and welcomes the opportunity to meet with current as well as prospective collaborators to discuss ongoing and future projects. If interested, please contact William Weiss (817-735-2111 or firstname.lastname@example.org) to arrange for a convenient dayand time to meet.
In addition, please plan on attending the following presentations:
Poster Session 172 – New Spins on Protein Synthesis Inhibitors
Monday, Sept. 08, 2014; 11:00am – 1:00pm
Pharmacodynamic evaluation of TP-271, a novel fluorocycline, in a neutropenic murine lung model infected with Streptococcus pneumoniae – presentedby Tim Murphy
Pharmacodynamics of the fluorocycline TP-271 in a neutropenic murine lung infection model with methicillin-resistant Staphylococcus aureus – presentedby Bill Weiss
Slide Session 200 – Clostridium difficile : Pathogenesis, Immune Response and Therapy
Monday, Sept. 08, 2014; 4:00pm – 4:15pm
Epidemic Clostridium difficile ribotype 027 strains are more virulent than other non-epidemic strains in the hamster CDAD model – presented by MarkPulse
April 24, 2014
The UNTHSC Pre-Clinical Services group will be attending the 24th ECCMID meeting in Barcelona, Spain from May 9-14 and welcomes the opportunity to meet with interested parties. Please contact William Weiss (817-735-2111 or email@example.com) to arrange for a convenient day and time tomeet.
In addition, please stop by the following poster presentations:
Saturday – May 10th – 3:30pm: Poster P0112 – Ileal Dosing of Nisin and Miconazole Combination is Efficacious in the Hamster Clostridium difficile Associated Disease Model (Presented by Mark Pulse, Assistant Director UNTHSC Pre-Clinical Services).
Sunday – May 11th – 1:30pm: Poster 0804 – DAV131, an oral absorbent-based product, exerts dose-dependent protection of hamsters againstmoxifloxacin-induced Clostridium difficile lethal infection (Presented by DaVolterra in conjunction with UNTHSC).
March 1, 2014
SMI presents Superbugs & Superdrugs – A Focus on Antibacterials
May 5 – 6, 2014, London, UK
“Research and Development in Neglected Diseases” (presented by William Weiss, Director of UNTHSC Pre-Clinical Services)
– Overview and Clinical Relevance
– Current therapies and issues
– Why pursue research of neglected diseases?
– New efforts and treatment options
June 7, 2013
The UNTHSC Pre-Clinical Services group will be in attendance at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in Denver, Colorado (September 10-13, 2013) and welcomes the opportunity to meet with current Sponsors as well as prospective collaborators to discuss ongoing and future projects. If interested, please contact William Weiss (817-735-2111 or firstname.lastname@example.org) to arrange for a convenient day and time to meet.
In addition, please plan on attending the following presentations by Mark Pulse, Assistant Director of the Pre-Clinical Services group:
Wednesday, Sept 11. – Slide Session 066 – Clostridium difficile: Pathogenesis
10:00 – 10:15 am : Dosing clindamycin before and after infection dramatically impacts disease outcome in the hamster Clostridium difficile -associated disease model
Thursday, Sept. 12 – Poster Session 143 – Antimicrobial Resistance and Immune Therapy
11:00am – 1:00 pm : Characterization of the programmed death 1 (PD1) and its ligand, PD-L1, in a murine cecal ligation model of sepsis
April 27, 2013
23rd ECCMID Meeting, Berlin, Germany
Oral Session – New Antibacterial agents
In vivo Efficacy of the novel monosulfactam BAL300072 alone and in combination with meropenem against clinically important gram-negative pathogens
William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
March 1, 2013
SMI Presents: Superbugs & Superdrugs – A Focus on Antibacterials
4th March to 5th March 2013, London, UK
AN UPDATE ON CURRENT ISSUES AND PROGRESS IN C. DIFFICILE DISEASE (CDAD)
William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
- A brief history and review
- The changing epidemiology and resistance development in CDAD
- Transmission, Virulence factors and clinical manifestations
- Surveillance, diagnosis and clinical testing
- Prevention, emerging therapies and potential for efficacy
November 12, 2012
UNTHSC Pre-Clinical Services (PCS) is pleased to announce the recent hire of Timothy Murphy who joins the group as Project Manager.
Tim comes to the group with 16 years experience in the drug discovery and pharmacology industry. He has previously held positions of increasing responsibility in ViviSource Laboratories, Arpida Inc., Enanta Pharmaceuticals and Wyeth Research. Tim brings with him extensive experience and expertise in the design and performance of anti-infective efficacy models: antibacterial and antiviral, pharmacology and oncology studies as well asPK/PD evaluations and vaccine discovery research. He has earned both B.S. and M.S. degrees in biology and has co-authored or presented numerousmanuscripts and presentations.
UNTHSC PCS welcomes Tim and looks forward to the contributions that he will make along with expanding the expertise and scope of testing that thegroup has to offer to our Sponsors.
July 30, 2012
The UNTHSC Pre-Clinical Services group will be in attendance at the 52nd Interscience Conference of Antimicrobial Agents and Chemotherapy (ICCAC) inSan Francisco, CA (September 9 – 12, 2012) and welcomes the opportunity to meet with current collaborators as well as prospective Sponsors to discussongoing and future research projects, utilizing our expertise to meet your R & D requirements. If interested, please contact William Weiss (817-725-2111or email@example.com) to arrange for a convenient day and time to meet.
April 2, 2012
UNTHSC Pre-Clinical services, in conjunction with Affinium Pharmaceuticals, presented their findings on the effects of AFN-1252, a novel fatty acidbiosynthesis inhibitor antibacterial agent, on the in vitro and in vivo expression of S. aureus virulence genes at the 22nd European Congress of ClinicalMicrobiology and Infectious Disease (ECCMID) in London, UK.
Presentation Summary: (full details and time can be found on the ECCMID Congress website)
Poster P2058 – AFN-1252 Alters In Vitro and In Vivo Staphylococcus aureus Gene Expression and Reduces Bacterial Counts in a Mouse GranulomaInfection Model
M. E. Pulse1, N. Kaplan2, J. Parsons3, C. O. Rock3, M. Kukula1, P. Nguyen1, J. Pierce1, D. Valtierra1, W. J. Weiss1, J. W. Simecka1
1UNTHSC, Fort Worth, TX, 2Affinium Pharmaceuticals, Toronto, Canada, 3St. Jude Children’s Res. Hosp., Memphis, TN
Exposure of S. aureus cultures to AFN-1252 resulted in the anticipated up-regulation of genes involved in the FAS II pathway associated with the FapRregulon and the unpredicted down-regulation of several virulence genes that are controlled by the SaeRS two-component regulator. In the MG infectionmodel, a single oral dose of AFN-1252 at 2 hours post-infection resulted in mean log10 CFU reductions of 2.9 – 3.1 in 24 – 48 hours after dosing. PKanalysis of this fluid revealed that the relative exposure (AUC) of AFN-1252 in the granuloma fluid was 85% of the corresponding plasma levels, andqRT-PCR of S. aureus RNA extracted from granuloma fluid indicated that fabH expression was up-regulated and virulence factor expression was down-regulated following the single dose of AFN-1252. AFN-1252 was also dosed consecutively (2, 26, 50 hours) in the MG model, which maximally reducedgranuloma-associated S. aureus counts by 5.3 log10 CFU within 72 hours of the first dose. AFN-1252 triggered the up-regulation of genes associated with the FASII pathway in S. aureus, and it simultaneously down-regulated virulence genes controlled by the SaeRS regulator. AFN-1252 not only alteredS. aureus gene expression in the granuloma fluid, but it also therapeutically reduced the CFU counts in the fluid as well.