Liu’s Lab

Yang Liu  MD. PhD.

Lab Mission

To elucidate the molecular mechanisms underlying retinal ganglion cell degeneration in ocular diseases. The ultimate goal of our laboratory is to develop novel therapeutic interventions to rescue retinal ganglion cells and promote neuronal regeneration.


  1. Mechanisms of neurodegeneration following optic nerve injury

Optic nerve injury induces apoptotic retinal ganglion cell death which mimics the pathology of glaucomatous neurodegeneration. New insights into pathogenic pathways involved in retinal ganglion cell degeneration will lead to the discovery and development of novel neuroprotective and regenerative strategies for treating retinal and central nervous system neurodegeneration.

  1. Establishing conditionally immortalized retinal cell lines

The progressive death of retinal ganglion cells is responsible for the glaucomatous loss of vision. Cultured retinal cells are commonly used to better understand the cell and molecular biology of these cell types and help dissect the pathogenic pathways associated with glaucoma. Immortalized cells lines will provide an unlimited and reproducible source of retinal cells that will be widely used in visual science research.





Recent publications


Graduate Student: Elliott Allums