UNTHSC study questions relevance of established risk factors for mild cognitive impairment among Mexican American elders
|Sid O’Bryant, PhD|
Advancing age, rather than established risk factors such as diabetes and hypertension, appears to be the only consistent predictor for mild cognitive impairment among Mexican American elders, according to UNT Health Science Center researchers.
The report suggests that previously established risk factors among non-Hispanics may not be applicable for Mexican Americans, said Sid O’Bryant, PhD, Associate Professor of Internal Medicine at UNT Health Science Center and lead author of the study in Alzheimer’s & Dementia.
“This means the disease may develop in Mexican Americans for different reasons than non-Hispanics,” he said.
Established risk factors such as gender, low education, obesity, diabetes and hypertension have previously been shown to be related to developing mild cognitive impairment, a transitional stage between normal aging and Alzheimer’s disease. Between 10 percent and 30 percent of adults 65 and older suffer from MCI, with approximately 10 percent to15 percent of these patients progressing to Alzheimer’s disease annually.
In the analysis of data from 1,628 participants, the researchers found 20 percent of Mexican Americans and 19 percent of non-Hispanics were diagnosed with MCI. Although Mexican Americans had a similar overall incidence of MCI, this ethnic group developed cognitive dysfunction on average 10 years younger than non-Hispanic whites, which may be related to a greater incidence of co-morbid diseases such as diabetes.
“The differences point to the need for more specific personalized medicine to treat Mexican Americans,” Dr. O’Bryant said. “Ethnicity and race are important to how we treat a number of diseases, and Alzheimer’s is no different.”
Dr. Leigh Johnson, Assistant Professor of Internal Medicine; Dr. James Hall, Professor of Psychiatry and Behavioral Health; Dr. Robert Barber, Associate Professor of Pharmacology and Neuroscience; and Dr. Meharvan Singh, Chairman and Professor of Pharmacology and Neuroscience, also participated in the research.
The study was funded by the National Institutes of Health, the Texas Alzheimer’s Research and Care Consortium, the Hogg Foundation for Mental Health and the Environmental Protection Agency.
By Jan Jarvis It started with one of those memory notifications that pop up on Facebook. The photo was of Collin Hadley running the Cowtown Half Marathon in 2014, and it hit his wife Emily like a ton of bricks. “I would give anything to be able to see Collin run again,” she sa...Read more
Feb 21, 2018
By Sally Crocker Dr. Marcy Paul has spent a lifetime following the teachings of Tikkun Olam, the Jewish concept of “repairing the world.” The foundations of Dr. Paul’s work in public health today, and her belief that every person has a responsibility to make the world better, have de...Read more
Feb 20, 2018
UNT Health Science Center (UNTHSC) and Lena Pope have teamed up to expand access to high-quality early learning experiences for children and families in Fort Worth with a new on-campus child development center. Lena Pope’s new Early Learning Center will serve the children of UNTHS...Read more
Feb 19, 2018
UNT Health Science Center has extensively revamped its system of tracking federally funded research projects after an internal review revealed flaws in its prior time and effort reporting practices. UNTHSC discovered the flaws in 2015 and subsequently self-reported the issues to the federal gover...Read more
Feb 16, 2018