Researchers hope $5.8 million grant will open window of opportunity for hormone treatment, brain health

February 7, 2013

With the graying of the world’s population, increasing numbers of women are reaching the age of menopause and will likely consider hormone therapy to treat menopausal symptoms including "hot-flushes."  But research is showing those hormone treatments also could help maintain a healthy brain by protecting brain cells. So, when should a woman initiate estrogen/hormone therapy and for how long?

Meharvan "Sonny" Singh, PhD, Chairman and Professor of the Pharmacology and Neuroscience Department at UNT Health Science Center, and his team recently received a five-year program project grant from the National Institutes of Health to continue their research that explores the biological basis for a finite "window of opportunity" for estrogen and progesterone treatment to benefit the brain.

Through the studies proposed in this $5.8 million grant, Singh’s team of scientists will identify some of the cellular and molecular machinery that is required for estrogen and progesterone to benefit the brain. Then the researchers intend to define how these cellular and molecular components of the brain expand the "therapeutic window" and help ensure that the hormones don’t have negative effects on brain function. 

Results could lead to safer and more effective therapeutic strategies for treating menopause and reducing the risk for various brain disorders (including Alzheimer’s disease) that increases during the post-menopausal period.

Diana Cervantes. Assistant Professor Biostatistics & Epidemiology
Dr. Diana Cervantes named among Fort Worth’s ‘most influential’ for public health service during the pandemic

By Sally Crocker Dr. Diana Cervantes has spent the last year keeping people informed and updated on all things coronavirus, and now she’s being recognized as one of Fort Worth Inc.’s “400 Most Influential People” for helping protect the community’s health during the pandemic. Dr....Read more

Jun 8, 2021

Opal Lee photo by Rodger Mallison/Fort Worth Star-Telegram
Celebrating Juneteenth

By Diane Smith-Pinckney On June 19 1865, Major General Gordan Granger marched into Galveston with a critical message: “The people of Texas are informed that, in accordance with a Proclamation from the Executive of the United States, all slaves are free.”  This was the opening se...Read more

Jun 8, 2021

Dr. Scott Walters
The realities of ‘breaking bad’ and how one HSC researcher is attacking the opioid crisis

By Sally Crocker He didn’t know it at the time, but when Dr. Scott Walters was growing up in San Diego in the mid 1980s, a next-door neighbor was concealing a homemade meth lab just across the fence and mere steps away from his bedroom window. For quite some time, concerned parents in his fa...Read more

Jun 8, 2021

MET Building at UNTHSC
HSC Health Diabetes Education Service Merits ADA Recognition

The prestigious American Diabetes Association (ADA) Education Recognition Certificate for a quality diabetes self-management education and support (DSMES) service was recently awarded to the HSC Health Diabetes Self-Management Education and Support Program. ADA believes that this service offers high...Read more

Jun 8, 2021