Viewbook Entries
| id | Name (full name) | Caption | Education List ([school]:::[location]~~[drgree info]) | Summary | Keywords | specialty |
|---|---|---|---|---|---|---|
| 26 | Suchismita Acharya Ph.D. | Research Assistant Professor, Pharmacology & Neuroscience | Indian Institute of Chemical Technology:::India~~Ph.D., Organic Chemistry UTSW Medical Center:::Dallas, TX~~Postdoctoral Fellow, Chemical Biology |
Our current research is focused on expanding the chemical toolbox for neural signaling and anti-inflammation/anti-oxidant pathways to understand the mechanism of action of the disease pathology associated with glaucomatous optic neuropathy, Alzheimer Diseases, Ischemic stroke as well as angiogenesis. Our lab integrates medicinal chemistry, chemical biology, bio-engineering, and drug delivery using nanotechnology. We employ synthetic organic and organometallic chemistry to generate small molecule library for low throughput as well as high throughput screening (target based as well as phenotypic). The ultimate goal of my lab is to produce novel therapeutic molecules which can be progressed to human clinical trials for these diseases. | Neural signaling, anti-inflammation/anti-oxidant pathways, glaucomatous, optic neuropathy, angiogenesis, stroke, peripheral arterial disease, nanoencapsulation technology, Alzheimer Disease | Medicinal Chemistry, organic synthesis, nanotechnology drug delivery, biodistribution study |
| 27 | Robert Barber Ph.D. | Exec Director and Associate Professor, Pharmacology & Neuroscience | Texas A&M University:::College Station, TX~~PhD, 1997, Genetics Texas A&M:::~~1981, Postdoctoral Fellow, Genetics |
Research in my group is focused on identifying genetic and epigenetic risk factors for neurodegeneration. Ongoing projects include efforts to use patterns of DNA variation and differential methylation to predict the risk and progression rate of Alzheimer’s disease. I am also interested in the biology of Alzheimer’s among Mexican Americans and how disease etiology may differ between this underrepresented ethnic group and Caucasians. A second area of research interest is how an individual gut bacteria profiles may impact risk for neurodegeneration and the age at onset of cognitive decline. Collaborations are established with researchers at UNTHSC and other Texas Alzheimer’s Research and Care Consortium member institutions across Texas, as well as the University of North Carolina at Chapel Hill. Active projects are ongoing with Drs. O’Bryant, Allen, Planz, Cross, Hall, and Cunningham at UNTHSC; Sohrabji and Miranda at Texas A&M Health Science Center; Huebinger and Reisch at UT Southwestern; Royall and Palmer at UT Health Science Center at San Antonio and Wilhelmsen and Tilson at the University of North Carolina at Chapel Hill. y Language: Work in my lab is focused on how an individual’s genetic makeup impacts their risk for Alzheimer’s disease, as well as their age at symptom onset and the rate of disease progression. The goal of our research is to use a combination of genetic variation, demographics and environmental factors to predict disease risk, age at onset and progression rate. We are also interested in how disease mechanisms and risk factors differ among ethnic groups, particularly between Mexican Americans and non-Hispanic whites. Research in our group is highly collaborative and active projects are ongoing with labs and scientists across the state and nation. | Alzheimer’s Disease, epigenetics, genetics, biomarkers | Neurological disease, genetics, biomarkers, health disparities |
| 28 | Alakananda Basu Ph.D. | Professor, Microbiology, Immunology & Genetics | University of Pittsburgh School of Medicine:::~~Ph.D., 1981-1985, Biochemistry University of Pittsburgh, Postdoctoral Fellow:::~~1985-1987, Biochemistry & School of Medicine, Molecular Biology |
The primary focus of our research is in signal transduction, especially in the context of cancer chemotherapy. A major research effort is to investigate how signal transduction pathways regulate cell survival and cell death. We have been studying how various signaling pathways, such as protein kinase C, Akt and mechanistic target of rapamycin (mTOR)/S6 kinase (S6K), regulate apoptosis (a genetically programmed cell death), autophagy (a process by which a cell recycles its own components to survive under stressful or nutrient-derived conditions) and senescence (loss of proliferative capacity of cells). We are using cellular, molecular and biochemical approaches as well as state-of- the-art technologies, such as proteomics and genomics to determine how an intervention with a signaling pathway can be exploited for cancer therapy. Another area of research is to investigate the molecular mechanism(s) of drug resistance. The ultimate goal of our research is to identify novel targets for cancer therapy, to exploit intracellular signaling systems to develop innovative strategies to treat cancer and to identify potential biomarkers to predict patient response to cancer therapy. | signal transduction, Akt, mammalian target of rapamycin (mTOR)/S6 kinase, apoptosis, autophagy, senescence, cancer, anticancer drug resistance | Cell Signaling, Cancer Biology, Experimental Therapeutics |
| 29 | Bruce Budowle Ph.D., Professor | Center for Human ID, Forensic Medicine | Virginia Polytechnic Institute:::Blacksburg, Virginia~~Ph.D., 1979, Genetics University of Alabama in Birmingham:::Alabama~~Postdoctoral Fellow, 1979-1982, Diabetes/Cancer Genetic Genetics |
Forensic genetics traditionally has been dedicated to analysis of human DNA markers for identity purposes to support criminal and civil investigations. However, with the demands of stakeholders and advances in technologies and bioinformatics, there is a substantial expansion of the applications of forensic genetics (or better yet forensic genomics). In addition to identification of humans associated with crime or missing persons due to mass disasters or other crimes, other areas of application include molecular autopsy and microbial forensics. Our research group has an advanced forensic genomics program using cutting edge genomics and technologies to effectively bolster current forensic and biosecurity capabilities. Some areas of interest are: computational genomics and bioinformatics; mixture interpretation; development of genetic diagnostics and detection capabilities; identification of novel genetic markers for human identification; population genetics studies; human microbiome studies for identification purposes; molecular autopsy (i.e. pharmacogenetics); and molecular mechanisms for DNA repair. These research efforts support the government in achieving its mission of law enforcement, combatting terrorism, providing biosafety and preserving national biosecurity, all for a healthier and safer society. | DNA markers, genetics, criminal and civil investigations | Forensic genetics |
| 30 | Gulab Zode Ph.D | Assistant Professor, Pharmacology & Neuroscience | UNT-Health Science Center:::TX~~Ph.D., Cell Biology & Genetics Howard Hughes Medical Institute (HHMI), University of Iowa:::Iowa City, Iowa~~Postdoctoral fellow |
My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage. We have developed two novel glaucoma mouse models as well as established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma | Glaucomatous, retinal ganglion cells, stress, glaucoma genetics | Pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs) |
| 31 | Yan Zhang Ph.D. | Research Assistant Professor, Department of Microbiology Immunology & Genetics | [[{"name":"University Of Tennessee Knox:::Knoxville, TN~~Ph.D., Civil Engineering"}],[{"name":"Chinese Academy of Science:::China~~Ph.D., Microbiology"}]] | I have interests in how the microbiome and host interact in health and disease. My research is to understand the role of microbiome in disease development (such as tick born disease, Phenylketonuria, Alzheimer’s disease, inflammation after severe injury and etc). Our projects include tick microbiome and disease associated human microbiome, using genomic and metagenomic approaches to investigate the microbiome dynamics. We also provide services for Next Generation Sequencing (IonTorrent, Miseq) and develop bioinformatics and statistical tools for metagenomic analysis. | tick borne diseases, phenylketonuria, Alzheimer’s disease genomic, metagenomic | Study of how the microbiome and host interact in health and disease. |
| 32 | Joseph Yuan Ph.D. | Assistant Professor, Physiology & Anatomy | [[{"name":"Johns Hopkins University:::Baltimore, MD~~Ph.D., Cell and Molecular Biology"}],[{"name":"Johns Hopkins University School of Medicine:::Baltimore, MD~~Fellow, Department of Neuroscience"}],[{"name":"University of Texas Southwestern Medical Center:::~~Postdoctoral Fellow, Department of Physiology"}]] | Occlusive arterial disease, or the pathological obstruction of arteries, is very common and prevalent in the Western countries. Major risk factors of this disease include aging, smoking, hypertension, diabetes, high-fat/high-cholesterol diet, and in-stent surgical procedures. This proposal examines why the smooth muscle layer of the arterial wall thickens as a result of these risk factors, leading to vessel constriction and pathological obstruction. We use a rat model of blood vessel wall thickening to study how interference with the expression of these inheritable traits/factors can possibly reduce and/or alleviate this arterial constriction. The underlying mechanism from risk factor to arterial smooth muscle remodeling is not well understood. Therefore, we want to identify the molecular players and cellular pathways responsible for this narrowing of blood vessels. Interfering with these genes and pathways may reduce the risk of this type of blood vessel constriction and, thus, become primary targets to inhibit or reduce the onset of occlusive arterial disease. | arterial disease, hypertension, diabetes, high fat/high-cholesterol diet | The study of occlusive arterial disease or the pathological obstruction of arteries. |
| 33 | Shaohua Yang Ph.D. | Professor, Pharmacology & Neuroscience | [[{"name":"UNT Health Science Center:::Fort Worth, TX~~Ph.D., Neuroscience"}],[{"name":"University of Florida:::Gainesville, FL~~Postdoctoral Fellow, 1997-2000, Neurosurgery"}]] | Our laboratory is interested in understanding the mechanism of brain disorders and the discovery of novel therapy for ischemic stroke, neurodegenerative diseases, and brain tumor. Our research has been focusing on the brain metabolism and using animal and cell culture models of ischemic stroke, neurodegenerative diseases, and brain tumor to address these issues. | metabolism, neurodegeneration, stroke, glioma. | Our research has been focusing on the brain metabolism and using cell culture and rodent models of ischemic stroke, neurodegenerative diseases, and glioma to address these issues. |
| 34 | Thomas Yorio Ph.D. | Professor, Pharmacology & Neuroscience | [[{"name":"Mount Sinai School of Medicine:::New York~~Ph.D. Mt Sinai School of Medicine Postdoctoral Fellow, Dept. Ophthalmology & Pharmacology"}]] | Dr. Yorio's laboratory focuses on glaucoma. Areas of interest include aqueous humor dynamics, identifying potential targets for neuroprotection with an emphasis and on the role of optic nerve astrocytes in neurodegeneration. Additional studies focus on neuroprotective properties of sigma-1 receptors and in the area of glucocorticoid pharmacology and ocular hypertension, specifically on understanding the role of glucocorticoid receptor (GR) beta in dampening the ocular hypertensive response of glucocorticoids. | Ocular Pharmacology; Neurodegeneration; Glaucoma; Aqueous Humor Dynamics, Optic Neuropathies, Astrogliosis | Ocular Pharmacology and Neuroscience |
| 35 | August Woerner Ph.D. | Research Assistant Professor, Center for Human ID | [[{"name":"University of Arizona:::Tucson, AZ~~Ph.D., Genetics"}],[{"name":"University of North Texas Health Science Center:::Fort Worth, TX~~Postdoctoral Fellow, Bioinformatics and Genomics"}]] | Dr. August Woerner is a Research Assistant Professor, and is part of Dr. Bruce Budowle’s research group at the University of North Texas Health Science Center at Fort Worth, Texas. He has a M.S. in Computer Science and Ph.D. in Genetics from the University of Arizona. His research interests are generally in the areas of computation and population genetics, with a focus in forensics, bioinformatics and machine learning. August’s current research projects run the gamut from streamlining bioinformatics pipelines, making them faster and more user friendly, to machine learning and statistical approaches to processing and calling MPS data, to inference problems in population genetics and genomics. | Bioinformatics, Data science, Machine learning, Forensic genetics, Population genetics, Genomics | I specialize in applying methods, introduced by myself or others, from bioinformatics, statistics and machine learning to problems in genetics and genomics. |
| id | Name (full name) | Caption | Education List ([school]:::[location]~~[drgree info]) | Summary | Keywords | specialty |
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