Research Studies

Recruiting Research and Clinical Trials:

Health disparities in Alzheimer’s disease and mild cognitive impairment among Mexican Americans  

Health and Aging Brain among Latino Elders (HABLE)
PI: O’Bryant, Sid
National Institute on Aging

HABLE places an emphasis on studying aging among Mexican Americans in Texas. Factors such as diabetes, physical conditions, lifestyle and memory and thinking problems differ among groups. Studying healthy and unhealthy aging in the Mexican American culture will hopefully allow us to create better interventions and treatment programs.

Participants will be compensated for their time and effort. For more information, contact Haydee Izurieta at (817) 735-2963

Exercise in Adults with Mild Memory Problems (EXERT)

PI: O’Bryant, Sid
University of California, San Diego
ClinicalTrials.gov Identifier: NCT02814526

The study will evaluate the effects of physical exercise on cognition, functional status, brain atrophy and blood flow, and cerebrospinal fluid biomarkers of Alzheimer’s disease in adults with mild memory impairment. Half of the participants will participate in stretching-balance-range of motion exercise program, while the other half will participate in a moderate/high aerobic training program.
Recruiting male and female participants between the ages of 65-89 inclusive with an MCI diagnosis.

If interested, please call or email Kamiah Moss at (817) 735-2963 kamiah.moss@unthsc.edu or Kim Brown, RN at (817) 735-2694 kim.brown@unthsc.edu


Active Research Studies and Clinical Trials:

Bi-functional Molecule for Glaucomatous Optic Neuropathy
PI: Acharya, Suchismita
BrightFocus Foundation

Epigenetic Risk Factors for Early Age at Onset of Alzheimer’s & MCI Among Non-Caribbean Hispanics
PI: Barber Jr., Robert C.
Alzheimer’s Disease Program

Interactions between testosterone and oxidative stress in dopamine neurons
PI: Cunningham, Rebecca
National Institute of Neurological Disorders and Stroke

Using Rodent Behavioral Models to Identify Substance Abuse Pharmacotherapies
PI: Forster, Michael J.
NIDA: National Institute on Drug Abuse

Susceptibility of Cerebellar Purkinje Cells to Oxidative Stress
PI: Huang, Renqi
William & Ella Owens Med Research Foundation

Direct Reprogramming of Reactive Astrocytes after Stroke
PI: Jin, Kunlin
William & Ella Owens Med Research Foundation

Impacts of the systemic milieu on stroke outcome
PI: Jin, Kunlin
National Institute of Neurological Disorders and Stroke

Magnetically Tissue Plasminogen Activator-Loaded Fe304 Nanorods Improve Thrombolysis Rates after Ischemic Stroke
(For: Jiangnan Hu)

PI: Jin, Kunlin
Sigma Xi

The Effect of Young and Aged Serum Exosomes on Ischemic Stroke Outcome
(For: Hongxia Zhang)

PI: Jin, Kunlin
American Heart Association

A novel mouse model to study motoric aging induced by benzodiazephine abuse
PI: Jung, Marianna
National Institute on Aging

HRSA GWEP Small Networking Meetings
PI: Knebl, Janice A.
American Geriatrics Society

Opioid Supplement
PI: Knebl, Janice A.
Health Resources & Service Administration

Workforce Enhancement Healthy Aging and Independent Living (WE HAIL)
PI: Knebl, Janice A.
Health Resources & Service Administration

D3 receptor compounds for the treatment of psychostimulant abuse 
PI: Luedtke, Robert
National Institute on Drug Abuse

Discovery of Functionally Selective Alzheimer’s Disease Therapeutics
PI: Luedtke, Robert
National Institute on Aging

PET Radiotracer for Imaging the Dopamine D3 Receptor
PI: Luedtke, Robert
University of Pennsylvania

Program Evaluation of the Project Towards No Drug Abuse Ground Zero Program
PI: Nejtek, Vicki A.
Recovery Resource Council

Effectiveness of Psychological & Cognitive Program Interventions in Veterans, Veteran Women, and Their Families
PI: Nejtek, Vicki A.
Recovery Resource Council

An Alzheimer’s blood test for primary care
PI: O’Bryant, Sid
National Institute on Aging

A blood test for screening into Alzheimer’s prevention trials
PI:O’Bryant, Sid
National Institute on Aging

Biomarkers of Alzheimer’s Disease in Down Syndrome
PI: O’Bryant, Sid
Columbia University Medical Center

A proinflamatory endophenotype to predict NSAID treatment response Alzheimer’s disease clinical trial
PI: O’Bryant, Sid
National Institute on Aging

Multi-omic Investigation of Exercise Effects in Mild Cognitive Impairment
PI: O’Bryant, Sid
University of California – Irvine

A novel neuroprotective approach for glaucoma 
PI: Prokai, Katalin T
National Eye Institute

Brain-selective therapy to alleviate hot flushed of prostate cancer patients
PI: Prokai, Laszlo
National Cancer Institute

A novel approach for improving cerebral tissue blood flow and oxygenation via pulsatile perfusion therapy
PI: Rickards, Caroline
American Heart Association

Potential Therapeutic Benefits of remote Ischemic Preconditioning vs Occlusive Exercise – An Acute Study
(For: Justin Sprick)

PI: Rickards, Caroline
NHLBI: National Heart, Lung & Blood Institute

Collective Action to Drive Systems-Level Change
PI: Severance, Jennifer
United Way of Tarrant County

Novel mechanistic targets of steroid hormones in the brain 
A program project grant to explore new ways that hormones affect the brain
More information 
PI:Singh, Meharvan
National Institute on Aging

Sigma-1 Receptor Agonists as a Novel Therapeutic for Brain Mitochondrial Dysfunction in Gulf War
Co-PI: Singh, Meharvan
Savannah State University

Sigma-1 Receptor Agonists as a Novel Therapeutic for Circadian Rhythm Disruption-induced Fatigue
Co-PI: Singh, Meharvan
Savannah State University

Dietary Targeting of Dihdrolipoamide Dehydrogenase for Stroke Tolerance
PI: Yan, Liang-Jun
National Institute of Neurological Disorders and Stroke

Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance 
PI: Yan, Liang-Jun
National Institute on Neurological Disorders and Stroke

Metformin and Vascular and Cognitive Impairment
(For: Kiran Chaudhair)

PI: Yang, Shaohua
American Heart Association

Neuroglobin: cell metabolism and neuroprotection 
PI: Yang, Shaohua
National Institute on Neurological Disorders and Stroke


Clinical Trial vs Clinical Study:

  • Clinical Trial – involves research participants and tests an intervention (potential drug, medical device, activity, procedure, etc.). It follows a pre-defined plan or protocol to evaluate the effects of a medical or behavioral intervention on health outcomes. By taking part in clinical trials, participants not only play a more active role in their own healthcare, but they also can access experimental treatments and help others by contributing to medical research.
  • Clinical Research – Observational study; aims to advance medical knowledge by studying people, either through direct interactions or though the collection and analysis of blood, tissue, or other samples.
  • For more information on the distinction between trials and research studies, please visit: National Institute for Health’s Clinical Research

This page was last modified on December 11, 2018