To understand mechanisms involved in steroid-induced glaucoma and the changes that steroid exert on trabecular meshwork. Also, our lab is dedicated to develop new neuroprotective therapeutics that will prevent loss of retinal neurons. The lab utilizes in vitro, in vivo, and ex vivo injury models combined with cellular, molecular biology, and immunohistochemistry techniques.
■Understanding mechanisms of steroid-induced trafficking of glucocorticoid receptors (GR) in trabecular meshwork. We have identified novel proteins known as importins and exportins that regulate shuttling of the GR receptors. Studies are underway to examine differences between steroid-sensitive and insensitive human cell-lines.
■ Proteomics analysis of steroid-treated trabecular meshwork cells overexpressing GR receptors.
■ Characterization of the role of acid-sensing ion channels (ASICs) in retinal degeneration. Preliminary data provided evidence for the involvement of ASIC1 in retinal degeneration and the use of ASIC blockers was neuroprotective in optic nerve crush model. Currently, we are testing new ASIC blockers for their protective effects following retinal injuries.
This page was last modified on December 14, 2016