PCORI Funding Announcement: Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research

Deadlines

Letter of Intent: May 13, 2025
Final Submission: September 3, 2025

Description

Patient Centered Outcomes Research Institute

With this PCORI Funding Announcement (PFA), PCORI aims to fund studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER).

For the Cycle 2 2025 Methods PFA, PCORI has identified the following areas that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies:

  • Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research
  • Methods to Improve Study Design
  • Methods to Support Data Research Networks
  • Methods Related to Ethical and Human Subjects Protections Issues in patient-centered CER

For more information, please see the announcement webpage.