Notice of Special Interest (NOSI): Ending the HIV Epidemic

Notice Number: NOT-AI-23-070

Deadline: January 7, 2024


The objective of this Notice of Special Interest (NOSI) is to solicit applications proposing research that is grounded in implementation science and can address the goals of the Ending the HIV Epidemic in the U.S. (EHE) initiative. The overall objective of EHE is to address the ongoing public health crisis with goals of first reducing the number of incident infections in the U.S. by 75% by 2025, and at least 90% by 2030, compared to the baseline infection rate in 2017. Projects will leverage research-community collaborations and scientific advances in HIV prevention, diagnosis, treatment, and outbreak response to advance the EHE goals, using innovations to tailor strategies for the multi-level barriers and strengths in communities disproportionately impacted by HIV.

Research Objectives

This NOSI invites research applications to advance the goals of EHE through the conduct of implementation research in communities disproportionately impacted by HIV in the EHE geographic priority areas. Studies of implementation strategies should build knowledge both on the overall effectiveness of the implementation strategies (implementation outcomes), as well as “how and why” they work (implementation mechanisms). Data on mechanisms of action, moderators and mediators, sustainability, and costs of implementation strategies will greatly aid decision-making on which strategies work for which interventions, in which settings, and for what populations.

For more information, please see the opportunity website.