Notice of Special Interest: Advancing Rheumatic Heart Disease Research (R01)

Notice Number: NOT-HL-23-106

Deadline: February 25, 2024


This Notice of Special Interest (NOSI) seeks to advance Rheumatic Heart Disease (RHD) research. There is a critical need to reduce RHD burden within low- and middle-income countries and low-resource settings in high-income countries. The NOSI calls for research proposals across the translational science spectrum (e.g., basic science, clinical research, and implementation and dissemination studies) within endemic settings to improve health outcomes.

This NOSI targets three notices of funding opportunity (NOFOs) to build robust evidence for prevention, detection, intervention, and implementation of evidence for limiting the burden of RHD. For example NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185 would support basic/discovery science research and longitudinal studies meant to gain a better understanding of GAS/ARF/RHD pathogenesis and progression in LMICs and low-resource settings. The Research Project Grant NOFO (Parent R01 Clinical Trial Required) (PA-20-183, would support mechanistic clinical trials to understand the biological or behavioral process, the pathophysiology of GAS/ARF/RHD, or the mechanism of action of an intervention. The Dissemination and Implementation Research in Health NOFO (R01 Clinical Trial Optional) (PAR-22-105 would support the contextual adaptation of EBIs in collaboration with communities to ensure their feasibility, acceptability and sustainability.

For more information, please see the funding announcement website.