NOSI: Alzheimer’s and Alzheimer’s-related Dementias (AD/ADRD) Focused Competitive Revisions to Existing NIH Grants that are not focused on AD/ADRD

Notice Number: NOT-AG-24-073

Deadline: March 7. 2025

Background

Since 2017, the National Institute on Aging (NIA) has sponsored a successful Administrative Supplement program to stimulate the field of Alzheimer’s disease (AD) and its related dementias (ADRD) (e.g., frontotemporal dementia, Lewy body dementia, Vascular Contributions to Cognitive Impairment and Dementia (VCID), and multiple etiology dementias). The program has been especially effective in bringing researchers from multiple scientific fields into the AD/ADRD research realm. Previous Notices regarding the program can be found above, under the Related Announcements heading. As of fiscal year (FY) 2025, instead of using Administrative Supplements, the program uses Competing Revisions.

Research Objectives

This NOSI invites Competitive Revision applications to existing single research project grants that are not focused on AD/ADRD. Revisions may not extend beyond the term of the current award period. Active awards with project end dates in FY 2026 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2025.

Research grants may also qualify if the current research is on a topic related to AD/ADRD (e.g., cognitive decline in aging, caregiving, the biology of neurodegeneration, genetics, imaging, computational methods, pain perception, biostatistical tools that have application to research on AD/ADRD). NIA’s website provides details on how AD/ADRD is defined and some examples of currently supported research. Awardees are expected to seek competing support to continue promising leads from the research supported through the Competitive Revisions. Additional information on areas of interest and Notices of Funding Opportunity Announcements can be found on NIA’s Funding Opportunities | National Institute on Aging webpage.

Awards that currently focus on AD/ADRD research are not eligible for this program. If an investigator is uncertain whether their project has an AD/ADRD focus, as defined by NIH, then the investigator should contact the Program Officer of the grant to be revised and inquire.

For more information, please see the opportunity webpage.