Funding Opportunity Number: RFA-AI-24-064
Deadline: December 4, 2024
Research Objectives and Scope
This funding opportunity will support applications for projects that discover and develop novel therapeutics directed to intracellular HIV targets and eliminate viral proteins by various mechanisms including, but not limited to, protein degradation, targeting of viral RNA through inhibiting RNA processing (splicing, translation, etc.) as well as degradation. Projects may include proof-of-concept studies in HIV-infected cell lines or primary cells. Studies may extend to the optimization of existing technologies or the development of new technologies. The goal is to identify lead molecules that target HIV RNA and proteins that have the potential to advance as preclinical candidates.
Examples of the types of research responsive to this NOFO include, but are not limited to:
- The design, optimization and testing of strategies for targeting HIV proteins (or the RNA that encodes them) for degradation.
- Small molecule strategies that interfere with processes involved in the transcription or translation of HIV RNA into protein.
- Strategies that target host proteins that have been shown to be essential for HIV replication.
- Development of new methods or technologies which can be used to eliminate HIV proteins.
For more information, please see the opportunity webpage.