Funding Opportunity Number: RFA-AG-25-026
Deadlines
Letter of Intent: October 7, 2024
Submission Date: November 7, 2024
Research Objectives
The goal of this NOFO is to help stimulate the emerging field of organelle communication and will help provide foundational information, and potential tool/method improvements, to further study the role of nuclear-mitochondrial communication in AD/ADRD. Applicants should briefly describe how their proposed studies will significantly improve our understanding of mitochondrial-nuclear communication and how changes in this communication can impact cellular biology in AD/ADRD. This NOFO will provide five years of funding to allow researchers to collect data on nuclear-mitochondrial communication, particularly using emerging tools/technologies. Topics of research include, but are not limited to, the following:
- Do AD/ADRD risk factor genes show altered expression with mitochondrial dysfunction?
- How does mitochondrial dysfunction impact epigenetic changes to AD/ADRD genes?
- What is the functional consequence of these epigenetic changes associated with mitochondrial dysfunction?
- Do different cell types exhibit different expression profile changes? Is there communication between peripheral cells?
- What role does mitochondrial heteroplasmy play in mitochondrial-nuclear communication and how does this impact AD/ADRD?
- How do changes to mitochondrial-nuclear communication impact AD/ADRD progression, AD/ADRD pathology, and/or neuronal health?
- Developing/applying new technologies to study mitochondrial dysfunction and nuclear-mitochondrial communication in AD/ADRD
For more information, please see the opportunity webpage.