Funding Opportunity Number: PA-25-245
Deadlines: June 5, 2025, October 5, 2025
Purpose
The National Institute on Alcohol Abuse and Alcoholism supports applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.
Research Objectives
Broadly, this NOFO seeks to advance five main areas in alcohol health services research: accessibility, increased treatment appeal, costs, dissemination and implementation, and health disparities. We are particularly interested in applications addressing the interaction between one or more of these five areas and those using study designs extending beyond standard randomized clinical trials, e.g., hybrid effectiveness-implementation, Sequential Multiple Assignment Randomized Trial (SMART), and multi-phase optimization strategy (MOST). Specific areas of interest include but are not limited to:
- Identification of specific barriers to accessing treatment
- Development and implementation of strategies to reduce barriers to treatment access
- Integration of AUD treatment into healthcare settings not specific to addiction, e.g., primary care, emergency departments, etc.
- Effectiveness of integrated behavioral health approaches, e.g., Collaborative Care Model, Patient Centered Medical Homes, etc.
- Implementation and sustainability of telemedicine for alcohol health services
- Costs associated with integrating alcohol treatment services into routine healthcare
- Workforce-related factors relevant for access, implementation, and sustainability of evidence-based treatment
- Geographic differences in alcohol control and related policies and their impact on alcohol health services
- Dissemination, implementation, and sustainability of evidence-based interventions for AUD
- Measures to assess the multiple components and dimensions of individual health disparities models (e.g., health literacy, access to health care, confidence in the proximal health system, socioeconomic status, sociocultural beliefs and practices related to alcohol use, and personal health care)
- Stigma, particularly as related to health disparity populations
- Development and adaptation of culturally-grounded interventions to address particular barriers to health services for AUD
For more detailed information, please see the opportunity webpage.