NIH R01: Advancing Methods for Safe, Noninvasive, Real Time Assessment of Placenta Development and Function Across Pregnancy

Funding Opportunity Number: PAR-22-237

Deadline: October 5, 2024, November 5, 2024


This Funding Opportunity Announcement (FOA) invites grant applications that seek to advance or clinically validate emerging novel approaches for the development of safe, real-time, non-invasive (or minimally invasive) methods to assess the development and function of the human placenta across pregnancy This will facilitate the development of valuable clinical and research tools to enhance our understanding of placental biology and improve our clinical management of pregnancy.

Scope of Research to be Performed

This FOA is for the advancement of novel methods for assessing the placenta’s real time in vivo status with the ultimate goal of human use across pregnancy. Special consideration will be given to applications that develop methods that are applicable throughout pregnancy, preferably starting in early gestation during the period of trophoblast invasion and remodeling of the uterine spiral arteries, and which facilitate assignment of relative risk for pregancy complications.

The placenta is a dynamic organ which changes over the course of pregnancy. To be helpful, assessments need to yield results within a time frame that reflects the current structural/functional status. However, real-time is not meant to imply instantaneous results.

Specific Requirements

All proposed research teams should include at least one obstetric clinician to provide insights into current or potential clinical functional or safety limitations of the chosen technology. They should have sufficient involvement to ensure that the proposed technology would be feasible in a clinical setting. It is strongly recommended that a biostatistician is included on any applications that propose clinical studies. The range of additional disciplines included may be either broad or relatively narrow (e.g., various subspecialties within a given field) as appropriate to the scientific goals of the application. The application should reflect the expertise of the proposed team. Strong academic-industrial partnerships are welcomed.

For more information, please see the opportunity webpage.