NIH Opportunity: Understanding Mechanisms and Outcomes of Trained Immunity

Funding Opportunity Number: PAR-24-111

Deadline: June 16, 2024 and October 16, 2024

Research Objectives and Scope

This Notice of Funding Opportunity (NOFO) solicits research projects that explore fundamental aspects of trained immunity. Such projects must align with NIAID’s mission to advance knowledge of immune system development and function, and better understand, treat, and prevent infectious and immune-mediated (*i.e.*, allergic, autoimmune, cell/tissue/organ transplant rejection) diseases. Areas of high priority include, but are not limited to, the following:

  • Identification of novel biomarkers associated with trained immunity induced by vaccines, vaccine adjuvants, and/or infectious pathogens
  • Basic studies of trained immunity in immune-mediated diseases
  • Elucidation of molecular and cellular mechanisms responsible for innate immune memory
  • Characterization of the functional implications of trained immunity, including impact on adaptive immune responses and/or disease outcomes
  • Determination of the duration and/or plasticity of trained immunity effects

Because basic characterizations of trained immunity are currently lacking, descriptive studies seeking to define immune signatures and phenotypes associated with trained immunity are allowed for applications submitted to this funding opportunity.

For more information, please see the announcement website.