Funding Opportunity Number: RFA-DA-25-008
Deadlines
Letter of Intent: July 13, 2024
Submission: August 13, 2024
Description
HIV infection and substance use are comorbid conditions that may exacerbate deleterious effects induced by each other. Recent studies have shown that HIV persists in latent reservoirs in a variety of tissues, including the brain. These latent HIV reservoirs, while being insensitive to antiretroviral therapies, retain the potential to produce infectious virus in response to a variety of activating signals. Addictive substances, such as cocaine, methamphetamine, opioids, and cannabinoids have the potential to modulate HIV persistence and reactivation by influencing host cell and immune mechanisms in the central nervous system (CNS).
This notice of funding opportunity (NOFO) is specifically focused on the identification of targets and pathways by which transcriptional activity of HIV can be suppressed in HIV reservoirs in the CNS in people with substance use disorder (SUD), and the application of emerging small molecule drug discovery approaches to identify novel compounds that can be utilized as pharmacological probes and drugs to suppress HIV transcription in the context of HIV-SUD comorbidity. Substances of interest include: opioids, nicotine, cocaine, methamphetamine, stimulants, psychedelics, addictive prescription drugs, cannabinoids, or combinations of these substances.
For more information, please see the opportunity announcement.