Notice Number: NOT-AG-23-037
Deadline: October 5, 2023
Research Objectives
This NOSI invites research that investigates cell-specific mechanisms of biomolecular condensates (BMCs) formation and function, investigate the role the nuclear pore complex (NPC) plays in regulating BMC formation and cell specific impact, and exploit existing tools or develop new tools to study the neurobiology of BMCs in aging and AD/ADRD.
Examples of topic areas responsive to this NOSI include, but are not limited to, the following:
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- Characterization of BMC formation/dissolution in different brain cell types (e.g., neurons, astrocytes, microglia, oligodendrocytes), focusing on cell-specific BMC differences in the context of normal aging and AD/ADRD.
- Approaches to elucidate how alterations to NPC function impact cell-specific BMC formation and function in aging and AD/ADRD.
- Investigate the impact modifiers (e.g., age, sex, protein modifications, or genetic variants) have on cell specific BMC formation and function in aging and AD/ADRD.
- Development of new model systems, including human induced pluripotent stem cells and organoids, to study cell specificity and cell-cell interactions in BMC alterations and function in aging and AD/ADRD.
- Development of novel tools or modification of current tools to visualize or modulate BMC formation and/or to divulge cell-specific phenomena in aging and AD/ADRD.
For more information, please see the announcement website.