Notice Number: NOT-HL-24-037
Deadline: January 08, 2028
Background
The heart, lung, blood, and sleep (HLBS) research community has transformed medicine by creating novel bioengineering technologies for HLBS diseases, including artificial hearts, pacemakers, implantable cardioverter-defibrillators, ventricular assist devices, stents, 3D bioprinting, organ-on-a-chip, tissue-engineered cardiac scaffolds, cell reprogramming technology, nanomaterials, molecular imaging agents, and cardiac patches. These examples demonstrate that bioengineering is a synergistic approach that crosses all HLBS technology-related areas. Further, bioengineering is unique because, unlike most stand-alone scientific topics, it demands collaboration across disciplines, which is critical to advancing needed technologies. The bioengineering community’s ability to achieve alternative and more effective therapies is an urgent need for NHLBI. It is envisioned that this targeted NOSI will serve as an opportunity to spur bold and novel bioengineering solutions and address critical research and clinical gaps and needs. It is expected that the end product of projects funded through this initiative may pursue further support from the NHLBI Catalyze Program.
Research Objectives
This NOSI invites discovery- and design-driven bioengineering research ideas that are important across the Institute and critical for future hypothesis-generating projects. Notably, this program emphasizes first-generation prototype development and initial feasibility studies. The NHLBI is interested in the development of new ideas for diagnostics, therapeutics, surgical technologies, artificial intelligence/machine learning/computational modeling tools, smart biomaterials for self-adjusting implants, molecular imaging, synthetic biology, and nanotechnologies, as applied to HLBS-related issues. Research funding under this NOSI will be limited to early-stage concept development that can ultimately feed into other translational program funding, such as the NHLBI Catalyze Program, for further development.
For more detailed information, please see the opportunity webpage.