Mechanistic Studies on Social Behavior in Substance Use Disorder

Funding Opportunity Number: RFA-DA-25-032

Letter of Intent: July 14, 2024
Submission: August 14, 2024


The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing mechanistic, transdisciplinary research on social behavior and its relationships with the onset, trajectory, and impact of Substance Use Disorders (SUDs) and comorbidities.

This NOFO is intended to support basic or early translational studies that may, but need not, be considered NIH clinical trials; this may include mechanistic clinical trials, observational studies, or secondary analysis of human data. Clinical trials supported by this funding opportunity are limited to mechanistic clinical trials. A mechanistic clinical trial is designed to understand a biological or behavioral process, the pathophysiology of a disease, biomarkers for a disease or response to treatment, or the mechanism of action of an intervention. It is not designed to test the safety or demonstrate the efficacy/effectiveness of an intervention. This NOFO is not intended to support studies designed to test the safety or demonstrate the efficacy of an intervention.

The goal of this initiative is to support innovative transdisciplinary research that will lead to new fundamental knowledge about neural mechanisms involved in the development and regulation of social behavior as a function of complex and dynamic social environments and social experiences, with particular attention toward social-environmental risk factors relevant to SUD and its comorbidities.

For more information, please see the opportunity website.