Academic Seminars

David P. Basile, Ph.D. to present seminar on 10/8/21 at 11:00 AM: “Orai1-dependent calcium signaling in Th17 cells: a new target for acute and chronic kidney disease”.
October 4, 2021

David P. Basile, Ph.D.
Professor, Department of Anatomy, Cell Biology & Physiology
Indiana University School of Medicine

“Orai1-dependent calcium signaling in Th17 cells: a new target for acute and chronic kidney disease”

Acute kidney injury (AKI) is a significant clinical disorder attributable to damage from factors such as ischemia/reperfusion or nephrotoxicity. AKI is associated with high mortality rates but is potentially reversible as the kidney has a remarkable recovery capacity. However, increasing evidence indicates that a common outcome of AKI is secondary progression of chronic kidney disease. Work highlighted from our group will focuses on the potential contribution of lymphocytes in the development of AKI as well as the AKI-to-CKD. We highlight evidence that lymphocytes, particularly Th17 cells, are strongly influenced by the activity of the store-operated Ca2+-channel Orai1, which is upregulated on lymphocytes in animal models of AKI. Inhibition of this channel attenuates both acute and chronic kidney injury in rodent models. In addition, Oria1+ cells are increased in peripheral blood of patients with AKI. Similarly, peripheral blood cells manifest an early and sustained increase in Orai1 expression in a rat model of ischemia/reperfusion, suggesting that blood cell Orai1 may represent a marker informing potential Th17 activity in the setting of AKI or the AKI-to-CKD transition.

Friday, October 8, 2021, 11:00AM-12:00PM, EAD-406*
University of North Texas Health Science Center
Fort Worth, Texas

Also available via Zoom