Letter of Intent: November 30, 2023
Submission: February 1, 2024
Award Amount: Up to $414,000
These awards support early investigators as they establish independence as diabetes researchers. Refer to the RFA for further details.
The American Diabetes Association is requesting letters of Interest (LOIs) for research focused on innovative re-
search to tackle the epidemic of Youth-Onset Type 2 Diabetes.
Type 2 diabetes (T2D) is increasing at alarming rates in adolescents and young adults. This disease entity poses unique challenges in both research and clinical care. The SEARCH for Diabetes in Youth Study has shown that the number of diagnosed cases of T2D in American youth is surging. From 2001 to 2017 the number of people under age 20 living with T2D grew by a shocking 95% with youth of ethnic/racial minorities and from disadvantaged backgrounds being disproportionately affected. Youth-onset T2D occurs in complex psychosocial and cultural environments that often make durable lifestyle changes elusive and medication adherence a struggle. Youth-
onset T2D clearly differs from Type 1 Diabetes (T1D). The pathophysiology of youth-onset T2D more closely resembles that of adult-onset T2D, particularly the link to obesity. Youth-onset T2D, however, displays unique aspects such as rapidly progressive beta cell decline, severe insulin resistance for handling glucose, and accelerated development of diabetes complications. Treatment options include the promotion of healthy lifestyles, metformin, insulin and GLP1 receptor agonists, yet remission is rarely achieved. As such, comprehensive, coordinated, and innovative strategies for the prevention, treatment, and remission of youth-
onset T2D are urgently needed.
The mission of the American Diabetes Association is to prevent and cure diabetes and improve the lives of all people affected by diabetes. This request for applications (RFA) is soliciting proposals to address key knowledge gaps in youth-onset T2D in order to better understand, prevent, treat, and ultimately induce remission for the rapidly increasing numbers of affected individuals. Applications that focus on disadvantaged lower socioeconomic level families and patients where the burden of disease is greatest are strongly encouraged.
For more information, please see the foundation website.