Lead Optimization
Dr. Yi-Qiang (Eric) Cheng Research Program |
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Current Research AimsBioactive natural products discovery from microorganisms and medicinal plantsFor treatment of cancer, infectious diseases, and aging-related conditions
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Genomics-Guided Discovery of Bioactive Natural ProductsOn-going GoalsMetabolic engineering to improve natural product yieldsPush promising drug candidates along the drug R&D pathwayIdentify additional uses of these compoundsDiscover and develop more bioactive natural products
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Dr. Kyle Emmitte Research Program |
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Current Research AimsMedicinal Chemistry and Drug DiscoveryDesign of bioactive small molecules for probing potential drug targetsOptimization of physiochemical pharmacological, and DMPK properties |
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Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5On-going GoalsBuild collaborations with pharmacologists and DMPK scientists interested in small molecule probe and drug discoveryDesign and optimize novel small molecules to answer important questions related to unmet medical needs, especially in neuroscience and oncology research |
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Dr. Jin Liu Research Program |
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Current Research AimsBiomolecular simulations: To understand how brain cells communicateComputer-aided allosteric drug development: For treatment of cancer and neurological diseases |
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Design Allosteric Modulators of alpha7-nAChR for Traumatic Brain Injury Treatment
On-going GoalsElucidate mechanism of neurotransmitter release machineryDevelop 3D cancer allo-networksEstablish collaborations for allosteric drug development |
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