Integrative Physiology
Fred Downey, Ph.D., Graduate Advisor
Research and Education Building 302
817-735-2080
Graduate Faculty: Caffrey, Carrol, Dimitrijevich, Downey, Grant, Gwirtz, Raven, Shi, Smith
Physiology is an essential foundation for clinical and experimental medicine. The physiologist seeks an understanding of the physical and chemical mechanisms of biological processes. Thus, physiology is the study of the function of living organisms and their various components. It encompasses normal and abnormal function and ranges in scope from an understanding of basic molecular and cellular functions to a cognizance of biological control systems and of the integration of bodily functions among multiple organ systems.
The Department of Integrative Physiology maintains an active and productive research program with special emphasis on cardiovascular physiology. Research interests of the faculty include cardioprotection, myocardial energy metabolism, cardiac endocrinology, coronary flow and flow regulation, cardiovascular responses to exercise, and mechanisms of blood pressure and blood volume regulation. Faculty programs are funded by extramural sources including the American Heart Association, the National Institutes of Health, American Diabetes Association, and the National Aeronautics and Space Administration.
Students may enter the program with a variety of academic backgrounds, providing that they have fulfilled prerequisite courses in biology, chemistry, physics, and mathematics. The graduate training program involves one year of courses in biomedical sciences and advanced courses in physiology, neurobiology, pharmacology, molecular biology and biochemistry. The program is designed to integrate the fundamental processes of molecular biology with organ system functions. Students participate in teaching and seminars and receive extensive training in techniques of contemporary physiological research. Doctoral students and Master of Science students perform original, publishable research and present their research findings at national scientific meetings. At the end of the first year, all graduate students must pass an oral physiology progress examination. One to two years are required to complete the Master of Science degree requirements. Three to five years are required to complete the Doctor of Philosophy degree requirements. It is expected that, prior to the awarding of the doctorate, the student will have published, have in press or have submitted two first-author publications in peer-reviewed journals.
Graduates with advanced degrees find employment in higher education, industry and government agencies.
Degree Plans
Typical degree plans leading to the M.S. and Ph.D. degrees are outlined below. The doctoral program offers the choice of two tracks, one focusing on Integrative Cardiovascular Science and the other focusing on Molecular Cardiovascular Science. It is advantageous to the student to begin graduate study in the summer or fall semesters. The degree plan may vary depending upon availability of course offerings in a given semester and each student's background and progress toward thesis or dissertation research.
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MS Degree Plan for Integrative Physiology |
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Year 1: Fall |
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BMSC 5600 |
Integrative Biomedical Sciences I: Principles of Biochemistry |
4 SCH |
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BMSC 5610 |
Integrative Biomedical Sciences II: Molecular Cell Biology |
4 SCH |
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BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
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BMSC 5960 |
Biomedical Ethics |
1 SCH |
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PSIO 5940 |
Seminar in Current Topics |
1 SCH |
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Electives |
1 SCH |
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12 SCH |
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Year 1: Spring |
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BMSC 5700 |
Integrative Biomedical Sciences III: Physiology |
3 SCH |
| BMSC 5705 | Integrative Biomedical Sciences IV: Pharmacology | 2 SCH |
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BMSC 5710 |
Integrative Biomedical Sciences V: Immunology and Microbiology |
3 SCH |
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BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
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BMSC 5950 |
Thesis |
3 SCH |
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12 SCH |
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Year 1: Summer |
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BMSC 5200 |
Biostatistics for BMSC |
4 SCH |
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BMSC 5950 |
Thesis |
3 SCH |
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7 SCH |
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TOTAL |
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31 SCH |
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PhD Degree Plan for Integrative Physiology, |
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Year 1: Fall |
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BMSC 5600 |
Integrative Biomedical Sciences I: Principles of Biochemistry |
4 SCH |
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BMSC 5610 |
Integrative Biomedical Sciences II: Molecular Cell Biology |
4 SCH |
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BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
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BMSC 5960 |
Biomedical Ethics |
1 SCH |
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PSIO 5940 |
Seminar in Current Topics |
1 SCH |
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Electives* |
1 SCH |
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12 SCH |
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Year 1: Spring |
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BMSC 5700 |
Integrative Biomedical Sciences III: Physiology |
3 SCH |
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BMSC 5710 |
Integrative Biomedical Sciences IV: Pharmacology |
2 SCH |
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BMSC 5710 |
Integrative Biomedical Sciences V: Immunology and Microbiology |
3 SCH |
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BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
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PSIO 5940 |
Seminar in Current Topics |
1 SCH |
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Electives* |
2 SCH |
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12 SCH |
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Year 1: Summer |
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BMSC 5200 |
Biostatistics for BMSC |
4 SCH |
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BMSC 6940 |
Individual Research |
2 SCH |
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6 SCH |
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Year 2: Fall |
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PSIO 5100 |
Cardiovascular Physiology I |
3 SCH |
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PSIO 5940 |
Seminar in Current Topics |
1 SCH |
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Electives* |
8 SCH |
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12 SCH |
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Year 2: Spring |
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PSIO 5110 |
Cardiovascular Physiology II |
3 SCH |
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PSIO 5940 |
Seminar in Current Topics |
1 SCH |
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Electives* |
8 SCH |
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12 SCH |
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Year 2: Summer |
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Electives* |
6 SCH |
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Year 3: Fall |
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Oral Qualifying Examination |
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Electives* |
6 SCH |
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Year 3: Spring |
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BMSC 6010 |
Grant Writing |
3 SCH |
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Electives* |
9 SCH |
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12 SCH |
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Year 3: Summer |
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BMSC 6950 |
Doctoral Dissertation |
6 SCH |
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Year 4: Fall |
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BMSC 6950 |
Doctoral Dissertation |
6 SCH |
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TOTAL |
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96 SCH |
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*Electives must include at least 1 additional SCH of Individual Research (BMSC 6940) and at least 3 of the following courses:
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PSIO 5200 |
Respiratory Physiology |
3 SCH |
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PSIO 5300 |
Renal Physiology |
3 SCH |
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PSIO 5400 |
Molecular Genetics of Cardiac and Vascular Disease |
3 SCH |
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PSIO 6050 |
Physiology of Skeletal and Smooth Muscle |
3 SCH |
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PSIO 6060 |
Cardiovascular Regulation During Exercise |
3 SCH |
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PSIO 6070 |
Advanced Endocrine Physiology |
3 SCH |
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PSIO 6080 |
Advanced Autonomic Nervous System Physiology |
3 SCH |
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PSIO 6090 |
Myocardial Metabolism: Concepts and Controversies |
3 SCH |
|
PhD Degree Plan for Integrative Physiology, |
||
|
Year 1: Fall |
||
|
BMSC 5600 |
Integrative Biomedical Sciences I: Principles of Biochemistry |
4 SCH |
|
BMSC 5610 |
Integrative Biomedical Sciences II: Molecular Cell Biology |
4 SCH |
|
BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
|
BMSC 5960 |
Biomedical Ethics |
1 SCH |
|
PSIO 5940 |
Seminar in Current Topics |
1 SCH |
|
|
Electives* |
1 SCH |
|
|
|
12 SCH |
|
Year 1: Spring |
||
|
BMSC 5700 |
Integrative Biomedical Sciences III: Physiology |
3 SCH |
|
BMSC 5710 |
Integrative Biomedical Sciences IV: Pharmacology |
2 SCH |
|
BMSC 5710 |
Integrative Biomedical Sciences V: Immunology and Microbiology |
3 SCH |
|
BMSC 5935 |
Introduction to Faculty Research Programs |
1 SCH |
|
PSIO 5940 |
Seminar in Current Topics |
1 SCH |
|
|
Electives* |
2 SCH |
|
|
|
12 SCH |
|
Year 1: Summer |
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CGEN 6030 |
Methods in Molecular Biology |
4 SCH |
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BMSC 6940 |
Individual Research |
2 SCH |
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6 SCH |
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Year 2: Fall |
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CGEN 6030 |
Cardiovascular Physiology I |
3 SCH |
|
PSIO 5940 |
Seminar in Current Topics |
1 SCH |
|
|
Electives* |
8 SCH |
|
|
|
12 SCH |
|
Year 2: Spring |
||
|
PSIO 5400 |
Molecular Genetics of Cardiovascular Disease |
3 SCH |
|
PSIO 5940 |
Seminar in Current Topics |
1 SCH |
|
|
Electives* |
8 SCH |
|
|
|
12 SCH |
|
Year 2: Summer |
||
|
BMSC 5200 |
Biostatistics for BMSC |
4 SCH |
|
|
Electives* |
2 SCH |
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|
6 SCH |
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Year 3: Fall |
||
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Oral Qualifying Examination |
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Electives* |
6 SCH |
|
Year 3: Spring |
||
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BMSC 6010 |
Grant Writing |
3 SCH |
|
|
Electives* |
9 SCH |
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|
|
12 SCH |
|
Year 3: Summer |
||
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BMSC 6950 |
Doctoral Dissertation |
6 SCH |
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Year 4: Fall |
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BMSC 6950 |
Doctoral Dissertation |
6 SCH |
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TOTAL |
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96 SCH |
*Electives must include at least 1 additional SCH of Individual Research (BMSC 6940) and at least 2 of the following courses:
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BIOC 5435 |
Molecular Aspects of Cell Signaling |
4 SCH |
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PSIO 6010 |
Functional Genomics and Proteomics |
3 SCH |
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PSIO 6090 |
Myocardial Metabolism: Concepts and Controversies |
3 SCH |
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And at least two of the following courses: |
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PSIO 5110 |
Cardiovascular Physiology II |
3 SCH |
|
PSIO 5200 |
Respiratory Physiology |
3 SCH |
|
PSIO 5300 |
Renal Physiology |
3 SCH |
|
PSIO 6050 |
Physiology of Skeletal and Smooth Muscle |
3 SCH |
|
PSIO 6060 |
Cardiovascular Regulation During Exercise |
3 SCH |
|
PSIO 6070 |
Advanced Endocrine Physiology |
3 SCH |
|
PSIO 6080 |
Advanced Autonomic Nervous System Physiology |
3 SCH |
|
PSIO 6090 |
Myocardial Metabolism: Concepts and Controversies |
3 SCH |
Advancement to Doctoral Candidacy Qualifying Examination
Prior to registration for Grant Writing (BMSC 6010), and before completion of 72 SCH of course work, doctoral students are required to pass an oral qualifying examination. The examination will be administered by a departmental examining committee, which will not include the student's mentor. The examination may address all aspects of physiology and, in addition, assess the student's research skills and aptitude.
Grant Writing (BMSC 6010)
After passing the qualifying examination, the student must register for Grant Writing (BMSC 6010) in the next long semester. In this course, students are required to submit an NIH grant application to their Advisory Committee. The grant application will describe the student's dissertation research project, and will serve as the student's dissertation proposal. Following a public, oral presentation of the research proposal in the grant application, the student will defend the grant application and research proposal before his/her Advisory Committee.
Upon approval of the grant application and the research proposal, the student is advanced to candidacy.
This page last updated Jun 05, 2008
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